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Objective To evaluate the value of diffusion tensor imaging (DTI)in the assessment of uterine fibroids by analyzing uterine fibroids and normal myometrium.Methods Forty-four patients with uterine fibroids confirmed by surgery were included in this study.DTI was performed using double gradient GE HDxt 3.0T and HD Cardiac coil.All data were transferred to GE AW4.5 Workstation software for data processing.Apparent diffusion coefficient(ADC),fractional aniso(FA),volume ratio aniso(VRA)and T2-weighted trace of uterine fibroids and normal myometrium were recorded.Diffusion tensor tractography (DTT)of uterine fibroids and normal myometrium were reconstructed and observed.The ADC,FA,VRA and T2-weighted trace of different regions of interest (ROI)were compared between uterine fibroids and normal myometrium.Results The ADC,FA,VRA and T2-weighted trace of uterine fibroids and normal myometrium were (1.65±0.32)×10 -9 mm2/s and (1.21±0.97)×10 -9 mm2/s,0.20±0.08 and 0.28±0.08,0.05 ± 0.05 and 0.09±0.07,344.22±66.1 9 and 318.97±98.48,respectively.The ADC of normal myometrium was higher than that of uterine fibroids (P =0.009).The FA and VRA of normal myometrium were lower than those of uterine fibroids (P =0.000,P =0.005). There was no statistically significant difference of T2-weighted trace between uterine fibroids and normal myometrium (P =0.1 74). There were obvious differences between uterine fibroids and normal myometrium in direction,arrangement and number of fibers. Conclusion DTI can be used to evaluate the structure difference between uterine fibroids and normal myometrium,which has the potential to improve assessment value of MRI for uterine fibroids.
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This study was undertaken to observe the biochemical changes in striatum of Parkinson's disease (PD) rat model by modified proton magnetic resonance spectroscopy. 12 SD rats were divided into model (n=7) and control (n=5) groups. At 3 weeks after the injection of 6-hydroxydopamine into right striatum, 1H-MRS on the striatum was taken by modified proton magnetic resonance spectroscopy, and then tyrosine hydroxylase (TH) immunostatining was used to visualize the changes of the neurons in substantia nigra and neurites in striatum. The results showed that TH positive neurons and neurites in the substantia nigra compacts (SNc) and striatum in the normal side of the rat model of PD were decreased (P < 0.05), which proved the successful establishment of PD models. The NAA/Cr ratio of the injected side striatum of model group was lower than that of the normal side (P < 0.05). The ratios of Cho/Cr showed no significant difference between the two sides (P > 0.05). These results indicated that the modified 1.5T 1H-MRS should be a noninvasive technique which could provide useful information about the biochemical metabolites in striatum for the study of PD in rat model.
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Animals , Female , Male , Rats , Corpus Striatum , Magnetic Resonance Spectroscopy , Methods , Oxidopamine , Parkinson Disease, Secondary , Metabolism , Rats, Sprague-Dawley , Tyrosine 3-Monooxygenase , MetabolismABSTRACT
Objective To investigate the X-ray and MRI manifestations of osteochondritis dissecans (OCD) and to compare the sensitivity of detection among different sequences. Methods Thirty-six OCD cases (thirty-eight knees) with complete data were selected and analyzed. The sagittal and coronal images were acquired on T 1WI, T 2WI, PDWI, and FLASH T * 2WI. MRI manifestations were analyzed retrospectively with double blind contrast method. The radiographies were obtained on the same day. The sensitivity of detection among different sequences was also compared. Results (1) The medial femoral condyle was the most commonly affected location in the knee (63.2%). The proportion of classical type, expanded type, and inferocentral type was 55.3%, 15.8%, and 28.9%, respectively. (2) On radiographs, the lesions typically appeared as a well circumscribed area of sclerotic subchondral bone separated from the remainder of the epiphysis by a radiolucent line. (3) Subchondral bone lesion was displayed as small and crescent-shaped ( n =38) on the sagittal image and as wedge (14) or short bar (24) shape on coronal image. The signal of the lesion was hypointense or isointense on T 1WI,surrounded by a hypointense or hyperintense (FLASH T * 2WI, T 2WI) line. The subchondral plate disappeared or became thinner. Interruption or disappearance of the hyaline cartilage could be seen sometimes. (4) The detection rate on T 1WI was higher than that of PDWI, T 2WI, and FLASH T * 2WI. Conclusion (1) Osteochondritis dissecans has specific X-ray and MRI manifestations. The abnormality of the hyaline cartilage and the subchondral bone can be displayed by MRI. Thus a proper diagnosis can be made. (2) The detection rate on T 1WI is higher than that of PDWI, T 2WI, and FLASH T 2WI.
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Objective To study MRI manifestation of the non-diver bone infarction. Methods Six cases of non-diver bone infarction involved 18 bones totally, in which 15 bones were confirmed by surgical operation and pathology. All cases were examined by MRI through T 1WI, T 2WI, PDWI, FLASH T 2WI, and by X-ray plain film. Result (1) Major MRI manifestation was moderate signal intensity on T 1WI and inhomogenous high signal intensity on T 2WI in the centers of the foci whose margin were rugged and rough bands which were low signal intensity on T 1WI and two layers on T 2WI. (2) MRI manifestation was atypical when focus was small (
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Objective To study the correlation between the contrast enhancement features on spiral computed tomography (SCT) and different clinicopathological characteristics in hepatocellular carcinoma (HCC).Methods Fifty cases (54 lesions) of HCC proved pathologically and examined with enhancement dual-phase SCT scanning (arterial phase and portal vein phase) were included in this study. The SCT features and the clinical details about resection and pathological differentiation were recorded. All the features of SCT were compared with some clinical and histopathological characteristics of HCC.Results The features of SCT were correlated with pathological characteristics of HCC. The pseudocapsula patterns were related with Edmondson's grade, and the enhancement patterns were associated with the diameter of tumor and intratumoral necrosis. There was a significant correlation between the high infiltration and severity (intrahepatic daughter foci, tumor-emboli in portal veins, lymphatic metastasis) on the SCT images and the diameter of tumor. The same correlation was found between the diameter of tumor on the SCT images and AFP value, and also between hepatic cirrhosis on the SCT images and HBsAg, the diameter of tumor.Conclusion This research confirms that SCT features are correlated with some clinicopathological characteristics of HCC.