ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the association of diabetes mellitus(DM) with colorectal cancer.</p><p><b>METHODS</b>Case-control study was performed to compare 486 patients with colorectal cancer (study group) and 533 patients without colorectal cancer (control group) in the Affiliated Nanhai Hospital of Southern Medical University between 2006 and 2009.</p><p><b>RESULTS</b>The incidence of DM was 12.1% in study group and 7.1% in the control group, and the difference was significant(P<0.01). On multivariate analysis, DM was independently associated with colorectal cancer (OR=1.886,95% CI:1.450~3.571). Colorectal cancer risk was increased in DM patients with a duration of 5-20 years(P<0.05), while colorectal cancer risk in those with a duration less than 5 years or more than 20 years did not change(P>0.05). No significant differences in tumor differentiation, invasion depth, lymph node involvement, distant metastasis and lymphovascular invasion were found between colorectal cancer patients with and without DM(all P>0.05).</p><p><b>CONCLUSION</b>Diabetes mellitus increases the risk of colorectal cancer, however, biological behaviors of colorectal cancer is not associated with diabetes mellitus.</p>
Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Case-Control Studies , Chi-Square Distribution , Colorectal Neoplasms , Pathology , Diabetes Mellitus , Logistic Models , Multivariate AnalysisABSTRACT
<p><b>OBJECTIVE</b>To explore the association of the changes of the jejunal mucosal structure and the tolerance of early postoperative enteral nutrition in gastric cancer patients at different ages.</p><p><b>METHODS</b>Thirty patients of gastric carcinoma undergone total gastrectomy were enrolled in this study, including 16 cases over 65 years old and 14 cases under 40 years old. The specimens of jejunal mucosa were taken during operation and were observed by light and electronic microscopes. The height and width of the jejunal villus and the thickness of the jejunal mucosa were measured. All the patients received enteral nutrition from the second postoperative day to discharge. The complications related to enteral nutrition, such as abdominal pain, abdominal distention, and diarrhea, were observed.</p><p><b>RESULTS</b>The height of the jejunal villus was longer in young age group than that of old age group. The width of the jejunal villus was shorter in young age group than that of old age group. The thickness of the jejunal mucosa was thinner in old age group than that of young age group. The changes of ultrastructure of the jejunal mucosal epithelial cell in old age group showed that microvilli are rare and disorder, mitochondrial cristaes were broken and dissolved. The young age group was normal in the ultrastructure. The complications related to enteral nutrition were more frequent in old age group than those in young age group, especially in abdominal distention and diarrhea (P<0.01).</p><p><b>CONCLUSION</b>The atrophy of jejunal mucosa in old age patients with gastric carcinoma lead to decrease the tolerance and increase the complications of the postoperative enteral nutrition.</p>