ABSTRACT
Objective To evaluate the effect and toxicity of cyberknife therapy combined with titanium silicalite-1 (TS-1) in treatment of local advanced pancreatic cancer (LAPC). Methods Ninety-five patients with LAPC were divided into two groups: cyberknife group (control group, n=45) received cyberknife therapy only, and combination group (n=50) received cyberknife therapy combined with TS-1. The adjuvant chemotherapy was performed 3 weeks after radiotherapy, and lasted for 4-6 cycles continuously. The effect, side effect, progression-free survival (PFS) and overall survival (OS) were recorded. Results In cyberknife group and combination group, the objective response rates (ORR, CR+PR) were 75.6% and 86.0% (P0.05) respectively. The indexes of total bilirubin and CA19-9 were significantly improved in the both groups after than before treatment with statistical significance (P0.05). In the median follow-up time of 20 months, the median PFS was 10.1 and 11.2 months and the median OS was 15.5 and 16.7 months in cyberknife and combination group, respectively (P>0.05). The incidences of digestive tract adverse reaction and myelosuppression in cyberknife group and combination group were 48.9% and 56.0%, 11.1% and 20.0%, respectively (P>0.05). There was no grade 3-4 serious adverse reaction. Conclusion Cyberknife combined with TS-1 is effective and safe for patients with LAPC, may improve local control rate, effective rate, PFS and OS.
ABSTRACT
OBJECTIVE: To study the effects of solanine on apoptosis of MCF-7 cells and explore the related mechanism.
ABSTRACT
Objective: To compare the lung injuries caused by drowning with equal volume of seawater and freshwater in rabbits. Methods: Twenty-four healthy New Zealand rabbits were randomly allocated to three groups (n = 8): control group(CG), seawater-drowning group (infused with seawater, 2 ml/kg) and freshwater-drowning group (infused with freshwater, 2 ml/kg). All rabbits were observed for 3 hours for breathing frequency, heart rate, mean arterial pressure (MAP), blood gas analysis and levels of TNF-α and IL-6. Pulmonary histopathology, ratio of wet/dry lung weight and permeation index of pulmonary capillary were recorded after the animals were sacrificed at the end of the experiment. Results: After infusion of seawater or freshwater, the respiration rates, serum levels of TNF-α and IL-6 were significantly increased (P<0.01), and the MAP was decreased (P<0.01), leading to hypoxemia and hypocapnia. Lung injuries were noticed in both seawater-drowning group and freshwater-drowning groups, with those in the former more persistent. The wet/dry ratio and permeation index of lung capillary were significantly increased after infusion in the seawater group compared with those in the other two groups (P<0.05). The cell number in the bronchoalveolar lavage fluid was significantly larger in the seawater-drowning group compared with that in the control group (P<0.01), and the lung injury was more severe than that in the freshwater group. Conclusion: Seawater infusion can lead to more serious and persistent lung injury in rabbits compared with equal volume of freshwater.