ABSTRACT
OBJECTIVE:To improve the level of rational use of drugs in hospitals.METHODS:Information on the application of the monitoring system for rational administration of drugs in our hospital was analyzed.RESULTS:Manifestations of irrational drug use in our hospital were mainly manifested as incompatibility of parenteral injection,drug interactions,the repetitive use of drugs,drug dosage exceeding the limit dose,medication warnings for specific group of people.CONCLUSION:Incidences for drug-induced diseases in our hospital have been reduced while the general rational drug-use level in our hospital has been improved through the monitoring system of rational use of drugs.
ABSTRACT
Aim To study the gender-based difference in genistein metabolism in rat liver microsomes in vitro.Methods Liver microsomes was obtained from male and female rats.The optimized system of enzyme catalytic reaction of genistein in rat liver microsomes was set up.The reaction velocity of genistein in female and male rat liver microsomes was assessed by incubating genistein with CYP1A2 antibody or specific CYP1A2 inhibitor furafylline,and the percentage of the relative metabolism of genistein of CYP1A2 was derivated by using the data of the reaction velocity.Results The metabolism of genistein by microsomes was inhibited by CYP1A2 antibody(1 ∶400)after incubation for 30 min.The percentage of the control metabolism of genistein of microsomes in male and female rat were 20.95%?2.13% and 13.73%?1.26%respectively(P