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[Objective] To observe the effect of Naolisu Granules (NG) for experimental cerebral ischemia in rats. [Methods] Rat models with cerebral ischemia was set up by embolization of middle artery. To observe the effects of NG on cerebrovascular permeability, cerebral water content was examined and cerebral Evans blue (EB) content was detected with chromatometry. Meanwhile, the effect of HG on cerebral histological structure was observed with hematoxylin and eosin(HE) staining method. [Results] NG decreased cerebral capillary permeability and cerebral edema ( P
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Objective: To observe clinical therapeutic effect of Naolisu Instant Granules for the patient of cerebral apoplexy at acute stage. Methods'. 90 cases were randomly divided into treatment group of 60 cases and control group of 30 cases. The treatment group was treated by oral administration of Naolisu Instant Granules and the control group was given Venoruton tablets, with oxygen inhalation, decreasing intracranial pressure, controlling blood pressure, preventing and treating infection, keeping water-electrolyte balance in the two groups. The changes of cumulative scores of TCM syndromes, cumulative scores of nerve function defect, and clinical therapeutic effects were compared between groups. Results: There were significant differences be- fore and after treatment in the changes of the cumulative score of TCM syndromes and the nervous function defect in the treatment group (P
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AIM: To optimize the milling and extraction rate for Naolisu Granules (Rhizoma Acori Tatarinowii, Radix Notoginseny, Pheretima Radix et Rhizoma Rhei, Radix Curcuma, Radix Ginserg Rubra, etc.). METHODS: The granularity of powder was determined by different micropowder processes. The process was studied by orthogonal design with the content of volatile oil, the yield of extract and the content of emodin. RESULTS: The optimum process of milling was that coarse powder was micropulverized for 20 min at -8℃ ～ -12℃ . The optimum extraction of volatile oil was distillated for 4 hs after volatile medical materials were macerated for 1h with 7 times amount of water. The optimum process of percolation was percolated by 300mL of 75% alcohol with 3.0mL?kg -1 ?min -1 after the medical material powders were macerated for 6 hs. CONCLUSION: These optimum processes are suitable for preparation of Naolisu Granules.