ABSTRACT
Peri-implantitis is one of the most important biological complications in the field of oral implantology. Identifying the causative factors of peri-implant inflammation and osteolysis is crucial for the disease's prevention and treatment. The underlying risk factors and detailed pathogenesis of peri-implantitis remain to be elucidated. Titanium-based implants as the most widely used implant inevitably release titanium particles into the surrounding tissue. Notably, the concentration of titanium particles increases significantly at peri-implantitis sites, suggesting titanium particles as a potential risk factor for the condition. Previous studies have indicated that titanium particles can induce peripheral osteolysis and foster the development of aseptic osteoarthritis in orthopedic joint replacement. However, it remains unconfirmed whether this phenomenon also triggers inflammation and bone resorption in peri-implant tissues. This review summarizes the distribution of titanium particles around the implant, the potential roles in peri-implantitis and the prevalent prevention strategies, which expects to provide new directions for the study of the pathogenesis and treatment of peri-implantitis.
Subject(s)
Humans , Peri-Implantitis/pathology , Titanium/pharmacology , Dental Implants/adverse effects , Osteolysis/pathology , Inflammation/chemically inducedABSTRACT
Magnetic nanoparticles (MNP) have been widely used as biomaterials due to their unique magnetic responsiveness and biocompatibility, which also can promote osteogenic differentiation through their inherent micro-magnetic field. The MNP composite scaffold retains its superparamagnetism, which has good physical, mechanical and biological properties with significant osteogenic effects and . Magnetic field has been proved to promote bone tissue repair by affecting cell metabolic behavior. MNP composite scaffolds under magnetic field can synergically promote bone tissue repair and regeneration, which has great application potential in the field of bone tissue engineering. This article summarizes the performance of magnetic composite scaffold, the research progress on the effect of MNP composite scaffold with magnetic fields on osteogenesis, to provide reference for further research and clinical application.
Subject(s)
Cell Differentiation , Magnetite Nanoparticles , Osteogenesis , Tissue Engineering , Tissue ScaffoldsABSTRACT
For complex implant cases, simple implantation could not achieve the desired therapeutic effect, and a multidisciplinary approach has become a general trend. Orthodontic treatment before implantation creates favorable conditions for subsequent implantation by increasing restoring three-dimensional space, improving occlusion of patients. It also stimulates the increase of autologous soft and hard tissue while biological potential of periodontal ligament is fully developed. The choice of operation time is vital to keep the level of soft and hard tissue at the implantation site, which improves the curative effect of implantation in terms of function and aesthetics. In this article, the orthodontic-implant combined therapy is briefly reviewed focusing on the three-dimensional space optimization, implant site enhancement by orthodontic extrusion and delayed orthodontic space opening.
Subject(s)
Humans , Dental Implants , Orthodontic Extrusion , Orthodontics , MethodsABSTRACT
Establishing a stable resin-dentin hybrid layer is an effective method to improve the adhesion durability of the restoration. The biomodification of dentin by cross-linkers can enhance the mechanical properties of collagen and resistance to enzymatic hydrolysis while, inhibiting the process of demineralization and promoting the remineralization of dentin, which has the potential clinical applicability of preventing dental caries and improving adhesive property. This review summarizes the biomodification of dentin type Ⅰ collagen by different cross-linkers.
ABSTRACT
Objective@#To observe the effect of adenosine triphosphate (ATP) phosphorylation on type Ⅰ collagen mineralization and explore the role of small molecule compound ATP in biomimetic mineralization.@*Methods@#Fourier transform infrared spectroscopy (FT-IR) was used to analyze the phosphorylation of collagen molecules by different concentrations (0, 25, 50, 100 mmol/L) of ATP. The concentration of 50 mmol/L ATP was chosen to construct the phosphorylated collagen mineralization model. Transmission electron microscopy (TEM) was used to observed the ultrastructure of mineralized collagen and the collagen mineralization rate was further calculated by ImageJ software. The surface morphology of the collagen gel ATP group and the control group was observed by scanning electron microscopy (SEM) and the elemental analysis was performed by using an X-ray energy spectrometer. The artificial demineralized dentin samples were mineralized for 2 days and 4 days to compare the effect of ATP on dentin remineralization by SEM.@*Results@#FT-IR analysis showed that the formation of new peaks at wavenumbers of 642, 818, and 902 cm-1 indicated that ATP can phosphorylate type Ⅰ collagen. Through TEM and SEM observation, the mineralization degree of type Ⅰ collagen and demineralized dentin pretreated with 50 mmol/L ATP were significantly higher than that of the control group. Compared with the control group [(31.65±1.62)%], the mineralization rate of collagen in the ATP group [(100±0)%] was significantly increased after 2 days of mineralization (P<0.05).@*Conclusions@#ATP phosphorylation can effectively promote the mineralization process of type Ⅰ collagen.
ABSTRACT
Peri-implantitis is a kind of serious complication after tooth implantation. The absorption of alveolar bone lead to the exposure of rough implant surface, which would result in poor long-term therapeutic effect. Implantoplasty promises a better long-term therapeutic effect than bone augmentation technique. This article will introduce implantoplasty from two aspects: therapeutic effect and its influencing factor, safety and effectiveness.
ABSTRACT
The use of various biomimetic methods to achieve remineralization of demineralized dentin and the formation of an organic matrix-inorganic mineral complex with a certain mechanical strength has been a research hotspot in recent years in the field of stomatology, and it also provides a new idea for the restoration of dentin defect. Dentin biomineralization is a process that simulates the mineralization of biological tissue in nature in which the remineralization of dentin collagen is induced and regulated by organic macromolecules. This review summarizes the process of remineralization of decalcified dentin regulated by non-collagenous protein analogues in vitro.
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the aesthetic outcomes of all-ceramic restorations by using four different porcelain materials on mimic-tetracycline pigmentation backgrounds.</p><p><b>METHODS</b>The translucency parameters (TP) of four different all-ceramic restorations (IPS e.max, Cercon, Lava, and Girrbach) were measured under white and black back grounds by using Datacolor 600, and the TP of each group (n = 8) was calculated. Five different mimic-tetracycline pigmentation teeth were printed with different colors by using a colorized printer as the prepared teeth backgrounds, under which the color parameters of each group were measured. The color differences with a standard 2M2 sample were calculated.</p><p><b>RESULTS</b>The TP values of the all-ceramic restorations were 15.67 +/- 0.58 for IPS e.max, 9.73 +/- 0.43 for Girrbach, 9.55 +/- 0.25 for Lava, and 7.56 +/- 0.43 for Cercon. The TP value of the IPS e.max group was significantly higher than those of the other three groups (P < 0.001). The deltaE of the IPS e.max group was 1.33 national bureau of standards (NBS) on the yellow background, and the deltaE of the Lava and Girrbach groups were 0.75 NBS to 1.47 NBS on the mimic-tetracycline pigmentation backgrounds of gray, dark gray, dark red, and light red.</p><p><b>CONCLUSION</b>The IPS e.max group has favorable TP. IPS e.max shows better aesthetic effects than the others when restoring mimic-tetracycline pigmentation teeth (on yellow background). Lava and Girrbach show better aesthetic effects on mimic-tetracycline pigmentation teeth (on gray, dark gray, dark red, and light red backgrounds).</p>
Subject(s)
Ceramics , Color , Dental Porcelain , LightABSTRACT
Objective To compare the orthodontic efficacy of the self-locking appliance and the ordinary straight wire appliance.Methods A total of 144 patients from March 2010 to March 2012 at the Department of Stomatology Orthodontic Surgery,Zhejiang Dongyang City People's Hospital were divided into observation group (n =72) and control group (n =72) according to the random number table.The observation group were treated with the self-locking appliance,and the control group were treated with the ordinary straight wire appliance.Results (1) The number of referral unconventional visits had no statistically significant difference between two groups (U =-1.65,P =0.0990).The number of routine visits of observation group was significantly less than that of the control group (U =-2.80,P =0.0052).(2) The VAS score of observation group was significantly lower than that of the control group (U =-8.47,P =0.0000).Conclusions The orthodontic efficacy of the self-locking appliance is obviously better than the ordinary straight wire appliance,and the former-caused pain is lighter.Therefore,the self-locking appliance is more suitable for orthodontic surgery.