ABSTRACT
The present study was conducted to investigate the preventive effects of squid ink polysaccharides [SIP] on the damage of sperm and reproduction induced by cyclophosphamide that is most commonly used for treating clinically cancers. Male Kunming mice exposed to cyclophosphamide were administered with SIP and were sacrificed to determine sperm parameters, testicular antioxidant ability and reproductive capacity. Data indicated that cyclophosphamide caused obvious changes in mice such as significant reduction [P<0.01] of glutathione reductase activity [GR], vitamin C [Vc] content and total antioxidant capacity [T-AOC] in the testes, as well as elevation [P<0.01] of abnormal rates of sperm and fetus, and a decrease in the total fetal count and average fetal count [P<0.01], were totally alleviated by SIP. From these findings it can be concluded that SIP decreases chemotherapeutic damage to sperm and reproduction in mice induced by cyclophosphamide
ABSTRACT
OBJECTIVE:To provide reference for improving teaching quality for pharmaceutical engineering major of Pharma-cology Course. METHODS:According to the current status and deficiencies on Pharmacology Course in universities,combined with own teaching experience and understanding,the author explored,four aspects. RESULTS & CONCLUSIONS:Pharmaceutical engineering major lacks specialized text books,and is in short of class periods and absence of experimant classes. Establishing rea-sonable teaching evaluation feedback mechanism,innovating teaching mode,setting up virtual simulation laboratory and sharing network resource may stimulate the enthusiasm of the students’self-learning,cultivate the students' ability to apply knowledge to practice and contribute to the improvement of teaching quality.