Advances of malignant pleural mesothelioma / 国际肿瘤学杂志

Malignant pleural mesothelioma (MPM)is a malignant cancer originated from pleural meso-thelial cell.The diagnosis of MPMis based on biopsy of pleura and immunohistochemistry.The current treat-ment of MPM is multimodality therapy including surgery,radiotherapy,chemotherapy and immunotherapy. There are two major surgical procedures:extrapleural pneumonectomy and pleurectomy/decortication.The main of radiotherapy is three-dimensional conformal radiotherapy.Cisplatinum combined with pemetrexed is the first-line chemotherapy for the patients with MPM.The principal targets for immunotherapy include regulatory T cells,cytotoxic T lymphocyte-associated antigen-4 and PD-1 .