ABSTRACT
Objective To investigate the factors of influencing plasma glucose level in STZ induced mice with chronic stress. Method We selected forty STZ mice and twenty normal Kun-ming(KM) mice, matched them with plasma glucose.Then the mice were divided into four groups:group A(STZ induced mice plus stress),group B(STZ induced mice),group C(stressing normal mice) and group D(normal mice).Stress factors were restraint, rotation and crowding. Their plasma glucose levels were determined every two weeks during the experiment. The contents of plasma insulin ,?-endorphin(?-EP) and Neuropeptide Y(NPY) in hypothalamus were measured after 6 weeks.Results After the chronic stress, in STZ mice(group A),the levels of plasma glucose and NPY were elevated significantly, the level of plasma insulin were gradually elevaled according to groups A,B,C,D,in sequences,there was obviously differences among the four groups significantly, ?-EP level increased according groups D,C,B and A slightly. Correlation analyses showed that there was negative correlation between the levels of plasma insulin and glucose(r=-0 4555,p