ABSTRACT
OBJECTIVE To investigate the inhibiting effect of Shenghuangketong Ointment on the herpes simplex virus(HSV)-Ⅰ and HSV-Ⅱ. METHODS Histocyte cultivation and cytopathic effect(CPE) were used to examine the inhibiting effect on the HSV-Ⅰ and HSV-Ⅱ. RESULTS EC 50 of Shenghuangketong Ointment on the HSV-Ⅰ and HSV-Ⅱ for HEP-2 cells was 0.94-1.12 mg/ml and 0.94 mg/ml,therapentic index(TI) was 4.0～4.7 and 4.7,respectively. CONCLUSIONS The Shenghuangketong Ointment has inhibiting effect on the HSV-Ⅰ and HSV-Ⅱ.
ABSTRACT
OBJECTIVE To study the antiviral effect of Shenghuangketong ointment(SO)in vivo experiments.METHODS The inhibition effect of SO on the HSV-infected mice with the estimation of its antiviral action.RESULTS SO had an obvious antiviral action and the inhibition effect on the HSV-infected mice.There was significant difference P