ABSTRACT
Objective To explore the effect of evidence-based nursing in elderly patients undergoing coronary artery bypass grafting. Methods From June 2016 to June 2018, 110 elderly patients aged 65 to 80 who underwent coronary bypass transplantation in cardiac surgery ward were selected by convenience sampling. The subjects were divided into control group (55 cases) and observation group (55 cases). The patients in the control group were given routine nursing method. The patients in the observation group were given evidence-based nursing according to routine nursing methods. The incidence of postoperative complications and the satisfaction of nursing care between the two groups were compared. Results The incidence of arrhythmia, mental disorder, respiratory tract infection, hypoxemia, knife-edge infection and pressure sore during mechanical ventilation were 15.3％(9/55),6.8％(4/55),7.5％(6/55), 12.1％(7/55),5.2％(3/55)in the observation group, 35.7％(21/55),27.1％(15/55),25.5％(25/55),12.7％(12/55),15.3％(9/55) in the control group, and the difference was statistically significant (χ2=2.423-17.476, P<0.05 or 0.01). The satisfaction degree was 96.36％(53/55)in the observation group, 81.82％(45/55) in the control group, and the difference was statistically significant (χ2 =5.9864,P<0.05). Conclusions Evidence-based nursing has a better effect in the nursing of elderly patients undergoing coronary artery bypass grafting, and it is worth popularizing in clinical nursing.
ABSTRACT
ObjectiveTo explore the expression of novel protein kinase C ε (PKCε) in normal prostate (NP) tissue, benign prostate hyperplasia(BPH), peficancerous (PC) tissue and prostate cancer (Pca), and study its correlation with the grade and stage of Pca.MethodsTen NP slides, ten BPH slides, ten PC slides and 43 Pca slides were collected from our hospital. These slides were routinely proceased and analyzed according to the requirement of immunohistochemical staining. Tumors were classified according to the 2002 TNM staging system. The grading system used in the study was based on the Gleason grade.ResultsWe was found that the expression of PKCεs in Pca (27/43) were significantly higher than those in NP(1/10), BPH (0/10) and PC (2/10) tissue, and the difference was statistically significant ( P ＜0.05 ). With regard to grade of prostate cancer, the expression of PKCε in Pca with Gleason score ≥8 group (12/13) was higher than the Gleason score 2 -4 group (4/10) and the Gleason score 5 -7 group (11/20). The difference was statistically significant (P ＜ 0.05 ). Moreover, the T3 and T4 stages had a more positive rate (10/12 & 9/10) than the T1 and T2 stages( 1/6 &7/15). There is statistically significant difference between early and advanced stage of prostate cancer ( P ＜ 0. 05 ). Furthermore, the positive expression of PKCε in prostatic carcinoma samples increased significantly in the metastasis group (9/10)compared to the non-metastasis group ( 18/33 ) ( P ＜ 0. 05 ), but the difference was not statistically significant between the concentration of prostate-specific antigen in blood serum ( P ＞ 0. 05 ).Conclusions PKCε is expressed in prostate cancer, and it correlates with the grade and stage of prostate cancer. PKCε may be related to the origin and the development of Pca, and it may be used as a prognostic factor for Pca.