ABSTRACT
【Objective】To investigate the therapeutic effect of Zhuyin Capsule(ZC)for the treatment of congestive heart failure(CHF).【Methods】Fifty SD rats were randomized into five groups: A(pseudo-operation),B(model),C(treated with hydrochlorothiazide 14.29?mg?kg~(-1)?d~(-1)),D(treated with ZC 0.26?g?kg~(-1)?d~(-1))and E(treated with ZC 0.51?g?kg~(-1)?d~(-1)).Except group A,rat models of CHF were established in other groups.Thirty-five days after the modeling,groups C,D and E were treated with corresponding drugs according to the experimental design for 2 days.Cardiac function and the pathological features of heart,liver and lung were examined.【Results】The changes in group A were as follows: heart rate became fast,blood pressure decreased,left ventricular end diastolic pressure(LVEDP)increased,the maximum rate of left ventricular pressure rise(+dp/dt_(max))decreased,ventricular cavity became enlarged and the wall was thin,and there appeared myocardial fibrosis,congested liver and edema in pulmonary alveoli,indicating the success of CHF model.High-dose ZC could relieved the above changes(P0.05).【Conclusion】ZC can decrease the preload and afterload of the heart,and reduce the pathological changes of heart,liver and lung in CHF rats,which may be one of its therapeutic mechanisms.