ABSTRACT
Based on the pharmacogenomics theory, this study developed a software system for interpretation of drug gene loci and guidance on clinical safe medication with the purpose of providing clinical guidance on the safety and effectiveness of drug use through accurate and efficient detection and interpretation of drug gene loci. The system infrastructure was built on a service-oriented architecture (SOA) design and Docker container virtualization approach to achieve a rapid and automatic interpretation of genetic results and best available drugs. The front end was established on HTML5 and JavaScript to realize visualization of analysis results and user interaction. The system was tested and validated to show robust performance which is reliable in clinical use. It will show high impact on the development of pharmacogenomics and clinical practice of patients with personalized medicine.
Subject(s)
Humans , Pharmacogenetics , Precision Medicine , SoftwareABSTRACT
Mirror therapy has been widely used in practice as an effective rehabilitaiton method. Mirror integrated therapy combined mirror therapy with some other technologies, such as virtual reality, functional electrical stimulation, augmented reality, etc., to enhance the task orientation, and improve the efficiency of treatment.
ABSTRACT
This article presents the design of a treadmill of comprehensive training experiment for rats. The treadmill is composed of six tracks and two of them were designed as conventional plane, two were designed to swing right and left, and two were designed to swing back and forth. The power was provided by six motors. The MSP430F149 is used as core to adjust the swing rate and the grade of electric shock. The IAR for MSP430 is used to design the software. The speed of the six tracks could be adjusted between 0 and 30 m/min. The swing tracks of back and forth can be swung for 3-25 times per minute and the swing tracks of right and left for 3-32 times. The electric shock can be divided into three levels, i. e. strong, middle, and weak level for each track. The digital comprehensive training treadmill can meet different training needs, and provide experimental data for mechanism research of some related diseases.
Subject(s)
Animals , Rats , Equipment Design , Exercise Test , Physical Conditioning, AnimalABSTRACT
It is very difficult for stroke patients to complete the action of squatting-standing because their equilibrium function ability has been seriously declined. It was necessary, therefore, to do a deep research on the action of human squatting-standing and to set up an accurate model and simulation. In our modeling research, the movements of upper limbs and head was neglected, and a seven-segment model was developed to establish the coordinate system of human squatting-standing action. It calculated the knee joint moment and hip joint moment during squatting and standing by utilizing Lagrange method, and then simulated this mathematical model by utilizing Matlab. Geometric model of human squatting-standing was developed and simulated in ADAMS which proved that the established Lagrange model was reasonable. It would also provide significant theoretical references for further study and development of squatting-standing rehabilitation training equipment.
Subject(s)
Humans , Biomechanical Phenomena , Computer Simulation , Hip Joint , Knee Joint , Models, Theoretical , Movement , Posture , Upper ExtremityABSTRACT
This paper discussed the application of upper extremity rehabilitation devices in rehabilitation evaluation after stroke, fo-cused on some typical kinds of upper extremity rehabilitation systems. It was analyzed that the way to obtain multiple parameter and evalua-tion indices during the progress of upper extremity rehabilitation evaluation, and viewed the development and application of upper extremity rehabilitation evaluation technology.
ABSTRACT
In this research, a new set of training methods was created and put into practice to train the body's sit-to-stand balancing ability, and controlling ability of body's gravity centre of patients with cerebrovascular diseases. It contains a series of motion trainings, including sitting position training, standing position training, sit-to-stand training and game training, etc. There is also a series of trainings of feedback included in this set of methods, such as internal feedback, external feedback, bandwidth feedback, conclusive feedback, visual feedback, acoustical feedback and so on. The trainings resulted in better controlling ability of body's centre of gravity in the sit-to-stand process of patients after a period of training. It indicated that these targeted-designed trainings, especially the feedback trainings, could effectively help the under-trained patients to have a better knowledge of their current situation, and in turn to have a better knowledge of which aspects they should take more training to achieve a better therapeutic effect.
Subject(s)
Humans , Equipment Design , Exercise Therapy , Methods , Hemiplegia , Rehabilitation , Movement , Physiology , Postural Balance , Physiology , Self-Help Devices , Stroke Rehabilitation , Weight-BearingABSTRACT
The function theory of an anesthesia vaporizer was studied and the geometry configuration was measured in this study. The internal gas flow and mixing process in the anesthesia vaporizer were simulated using CFD method. Applying tracking in turbulent flow to stochastic particle, for the droplet of anesthesia drug, the moving track of droplet was traced. Based on the results, the internal gas flow variation, the concentration distribution of anesthesia drug volatilization process and mixing process with gas were ascertained. Numerical simulation results showed that, the diluted gas velocity reduction of internal flow in the anesthesia vaporizer was higher. Because of the anesthesia vaporizer geometry, the mixing process between anesthesia drug vapor and diluting gas was not homogeneous. This also influenced the stability and accuracy of anesthesia drug concentration. The optimization precept of anesthesia vaporizer is ascertained.
Subject(s)
Humans , Anesthesia, Inhalation , Computer Simulation , Imaging, Three-Dimensional , Nebulizers and Vaporizers , Reference Standards , Numerical Analysis, Computer-AssistedABSTRACT
Objective To study the impact of active control of the trajectory of the center of gravity on the effectiveness of balance training and balance assessment. Methods Two groups of subjects ( group 1 30-45 years old, group 2 45-60 years old ) were evaluated and trained using both active center of gravity trajectory control and static balance methods. Results The percentages of success in controlling the center of gravity were the same when both groups were trained using static balance. Group 1's success percentage was higher than that of group 2 after active center of gravity trajectory training. Their affected lower limbs performed better in wave trace training than after static balance training, and performance improved with increased wave trace amplitude. Conclusions Wave tracing can stimulate the lower limbs of patients with active control force and improve their balance. The wave assessment is superior to static assessment, as it can objectively reflect ability in active center of gravity control and adjust the lower limbs of subjects whose static balance ability is at the same level.
ABSTRACT
Obstacles in pharyngoesophageal function are characterized clinically by dysphagia.At present,the treatment for dysphagia is broadly divided into two ways:balloon expansion therapy and electrical stimulation therapy.Balloon dilatation device for achalasia of cricopharyngeal muscle is design based on the principle of expansion treatment to stimulate cricopharyngeal muscle contraction and dilatation through the pressure of balloon dilation.At work,the water was filled in balloon catheter through the electronic charge pump to pressurize to reach a certain pressure of the balloon dilatation,and the drain valve drained water at prescriptive speed until it reaches a certain contraction of the balloon pressure,followed by water filling in the balloon catheter.This operation was repeated operation,resulting in a compression cycle to cricopharyngeal muscle,promote its contraction and dilatation.Patients can gradually restore autonomy of swallowing.The device is easy to operate,safe and reliable.The doctor can fill water in the balloon catheter at certain time and quantity to achieve the treatment of achalasia of cricopharyngeal muscle.
ABSTRACT
High-frequency surgical equipment electrical safety is analyzed based on safety testing standards for GB9706.4,and high-frequency leakage current of GD350-Btype high-frequency surgical equipment is tested by QA-ES.The safety of high-frequency surgical equipment is discussed.