ABSTRACT
Objective: To enhance the dissolution rate in vitro and bioavailability in vivo of the active components of extraction of Radix Arnebiae seu Lithospermi. Methods: Solid dispersion of extract of Radix Arnebiae seu Lithospermi were prepared with solid dispersion technology, X ray diffraction and stability experiments were also carried out. Results: The dissolution rates in vitro of the active components of extraction of Radix Arnebiae seu Lithospermi solid dispersion were obviously raised and stable, and the solid dispersion was not easy to age. Conclusion: The dissolution rate in vitro of the active components in Radix Arnebiae seu Lithospermi can be inproved greatly by the solid dispersion using PVP and HPMC as a carrier.
ABSTRACT
AIM: To extract the effective composition from Radix Arnebiae seu Lithospermi and make it into the vagina effervescent tablet. It would be convenient and effective to treat the disease for the patients. METHODS : To sift the technology of extracting the effective composition by experiment and find out the prescription of the vagina effervescent tablet,its time of disintegration and the quantity of producing foam can accord with the principle of the vagina effervescent tablet in Chinese pharmacopoeia. RESULTS : The technology of extracting the effective composition and the prescription of the vagina effervescent tablet by experiment are practical. CONCLUSION : It is convenience for patients to take vagina effervescent tablet of Radix Arnebiae to treat their diseases