ABSTRACT
The wind, phlegm, and blood stasis are important pathogenic factors of cough variant asthma in children, and they are also the pathological products in the occurrence and development of this disease. They have typical pathogenic characteristics. The main pathogenesis characteristics of cough caused by wind, phlegm and blood stasis are as follows that external wind attacks the lungs and induces internal wind, phlegm and dampness accumulates in the lungs, and the lungs fail to declare and descend, and blood stasis obstructs the collaterals and stagnation of Qi. The wind, phlegm, and blood stasis have their own pathogenic characteristics, and their cough-causing also have their own pathogenic characteristics and clinical characteristics. Based on the characteristics of wind, phlegm, and blood stasis, the application of medicine based on the differentiation of symptoms and signs can effectively prevent and treat this disease, and provide theoretical basis and treatment ideas for the treatment of cough variant asthma in children with Chinese medicine.
ABSTRACT
Objective To prepare a set of serum cardiac troponin I quality control materials for testing and evaluate the homoge‐neity and stability .Methods Mixed serum were collected ,filtered ,distributed ,storaged at -20 ℃ according to the experimental design .The homogeneity of serum pools was evaluating according to the CNAS‐GL03 Guidance .The stability of cTnI in human ser‐um was examined using an accelerated stability testing protocol according to the Arrhenius equation .Further ,the effect of stability was verified by long term test .Results In the homogeneity evaluation the results showed that there were insignificant difference between the control materials (P>0 .05) .Stability analysis ,the control should not exceed 2 times by freeze‐thawing ;constant tem‐perature accelerated test results showed that the serum levels of cTnI degraded in accordance with the change of chemical first‐order reaction kinetics .Arrhenius‐plots indicated that the cTnI control materials were stable for at least 7 days at 4 ℃ and 19 months at-20 ℃ ,respectively .Control materials were monitored for 9 months ,the results are stable ,and consistent with the constant tem‐perature acceleration .Conclusion The homogeneity and stability of serum cTnI is good and can be used in clinical quality control .