Association between temperature and mortality: a multi-city time series study in Sichuan Basin, southwest China

BACKGROUND@#There are few multi-city studies on the association between temperature and mortality in basin climates. This study was based on the Sichuan Basin in southwest China to assess the association of basin temperature with non-accidental mortality in the population and with the temperature-related mortality burden.@*METHODS@#Daily mortality data, meteorological and air pollution data were collected for four cities in the Sichuan Basin of southwest China. We used a two-stage time-series analysis to quantify the association between temperature and non-accidental mortality in each city, and a multivariate meta-analysis was performed to obtain the overall cumulative risk. The attributable fractions (AFs) were calculated to access the mortality burden attributable to non-optimal temperature. Additionally, we performed a stratified analyses by gender, age group, education level, and marital status.@*RESULTS@#A total of 751,930 non-accidental deaths were collected in our study. Overall, 10.16% of non-accidental deaths could be attributed to non-optimal temperatures. A majority of temperature-related non-accidental deaths were caused by low temperature, accounting for 9.10% (95% eCI: 5.50%, 12.19%), and heat effects accounted for only 1.06% (95% eCI: 0.76%, 1.33%). The mortality burden attributable to non-optimal temperatures was higher among those under 65 years old, females, those with a low education level, and those with an alternative marriage status.@*CONCLUSIONS@#Our study suggested that a significant association between non-optimal temperature and non-accidental mortality. Those under 65 years old, females, and those with a low educational level or alternative marriage status had the highest attributable burden.

Analysis on the imported Coronavirus Disease 2019 related cluster epidemic in rural areas of Chengdu / 中华预防医学杂志

An epidemiological investigation was carried out on a local cluster of outbreak caused by imported cases of Coronavirus Disease 2019 (COVID-19) in rural areas of Chengdu in December 2020, to find out the source of infection and the chain of transmission. According to

ras Gene Damage Induced by Organic Concentrate of Drinking Water / 环境与健康杂志

Objective To detect the DNA damage of ras gene induced by organic concentrate of drinking water using randomized terminal linker-dependent PCR. Methods The single-stranded probes of exons of rass gene in human were prepared. The TK6 cell was treated with organic concentrate of drinking water, then genomic DNA was amplified by RDPCR and detected by Southern hybridization with the probe. Results The clear hybridized band induced by organic concentrate of tap water could be seen in the position of exon 2 of N-ras gene,but in those of exon 1 of N-ras, exon 1 and 2 of H-ras gene it could not be detected. No hybridized bands induced by organic concentrate of raw water were seen in any position. Conclusion The organic concentrate of drinking water can cause the DNA damage of ras gene and it is considered as a kind of genotoxic substance.