ABSTRACT
Objective :To explore influence of small and dense low density lipoprotein (sdLDL) on in-stent restenosis after percutaneous coronary intervention (PCI).Methods : A total of 631 CHD inpatients ,who received PCI in our department from Feb 2015 to Feb 2017were followed up for 12 months ,and 240 cases were successfully followed up . According to coronary angiography (CAG) results ,the vascular diameter stenosis ≥50% regard as in-stent resteno-sis ,all patients were divided into restenosis group (n＝105) and no stenosis group (n＝135).Another 35 healthy volunteers undergoing physical examination simultaneously were treated as healthy control groups .Serum levels of sdLDL ,serum lipid TC ,TG ,HDL-C and LDL-C were measured and compared among all groups .Correlation be-tween serum sdLDL level and Gensini score was analyzed in CHD patients .Results : There were no significant difference in levels of serumlipids between restenosis group and no stenosis group , P＞ 0. 05 all.Compared with healthy control group ,there was significant rise in serum sdLDL level [ (0.451 ± 0.135) mmol/Lvs .(0.673 ± 0.281) mmol/L] in CHD group , P＝0.001 ;compared with no stenosis group ,there were significant rise in serum sdLDL level [(0.606 ± 0.276) mmol/L vs.(0.695 ± 0.304) mmol/L] and Gensini score [(40.23 ± 9.24) scores vs. (58.42 ± 10.37) scores] in restenosis group (P＝0.019 ,0.001) respectively.Linear correlation analysis indicated that serum sdLDL level was significant positively correlated with Gensini score in CHD patients ( r＝ 0.514 , P＝ 0.032).Conclusion :Elevated serum sdLDL level suggests high risk of in-stent restenosis in CHD patients .It can provide reference for disease condition assessment and adverse event prevention after PCI .