ABSTRACT
Epigenetic is a hotspot of post-genomic era research, and epigenetic modification is a mechanism in the study of cardiovascular disease. Myocardial ischemia-reperfusion injury (MIRI) is one of the problems in the cardiovascular disease, and many experimental interventions are reported in the protection of the ischemic myocardium in experimental animals. However, with the exception of early reperfusion, none has been translated into clinical practice. There is an advantage of traditional Chinese medicine (TCM) in the regulation of epigenetic modification, and pathogenesis of myocardial ischemia-reperfusion injury. This review article is prepared to cover the research progress in the treatment of myocardial ischemia-reperfusion injury by TCM with a focus on epigenetic regulation. The epigenetic regulation is documented in TCM theory through a systematic review of the protecting drugs in the MIRI development guidelines.
ABSTRACT
Coronary artery heart disease (CHD) is one of the common cardiovascular diseases in clinical. The morbidity and mortality of CHD recently continue increasing in our country, which has aroused wide attention. Many studies confirm that traditional Chinese medicine has better therapeutic effect on CHD. Guanxin Danshen formula, widely used in the treatment of CHD, consists of Salviae Miltiorrhizae Radix et Rhizoma, Notoginseng Radix et Rhizoma and volatile oil from Dalbergiae Odoriferae Lignum, and has the efficacy in promoting blood circulation to resolve stasis, regulating the circulation of Qi and alleviating pain. This review summarized the pharmacologic effects and mechanism of Guanxin Danshen formula and its effective components in the treatment of CHD to provide reference for its fundamental research and clinical application.
ABSTRACT
Reperfusion is the most effective treatment for acute myocardial infarction, markedly reducing mortality and morbidity. Reperfusion however induces necrotic and apoptotic damages to cardiomyocytes, that were viable prior to reperfusion, a process called myocardial ischemia/reperfusion injury(MI/RI). Over the past 30 years, hundreds of experimental interventions (both pharmacologic and nonpharmacologic) have been reported to protect the ischemic myocardium in experimental animals; however, with the exception of early reperfusion, none has been translated into clinical practice. The population-based survey assessed men have about twice the total incidence of morbidity and mortality of women, and the sex gap in morbidity tends to diminish after age 45 years. So hormone replacement therapy (HRT) is given to treat the MI/RI, and lots of studies shows that the side effect is greater for estrogen, compared with phyestrogen. In this article, we review the important pathogenesis of myocardial ischemia reperfusion injury, the prevention and limitations of HRT. And we highlight the mechanism of phyestrogens treatment the MI/RI in experiment. The aim is to provide the theoretically new way of develop the safe and effective products for the researchers.
Subject(s)
Animals , Humans , Myocardial Ischemia , Drug Therapy , Myocardial Reperfusion Injury , Drug Therapy , Phytoestrogens , Plant ExtractsABSTRACT
OBJECTIVE: To study the chemical constituents of Whole Plant to the whole plant of Veronicastrum axillare(Sieb. et Zucc.)Yamazaki. METHODS: The compounds were isolated and purified by various chromatographic techniques, and their structures were identified on the basis of physicochemical properties and spectral analysis. RESULTS: Twenty-three compounds were identified as 5-hydroxy-7, 4'-dimethoxyflavone(1), acacetin(2), 5, 7, 4'-trihydroxy-8-methoxyflavone(3), 5, 7, 3'-trihydroxy-4'-methoxyflavone(4), luteolin(5), oleic acid(6), syringaresinol(7), glyceryl ferulate(8), cinnamic acid(9), p-hydroxycinnamic acid(10), caffic acid(11), ferulic acid(12), 3, 4-dimethoxycinnamic acid(13), p-hydroxybenzoic acid(14), protocatechuic acid(15), vanillic acid(16), isovanillic acid(17), protocatechuic aldehyde(18), hydroquinone(19), 1, 2, 4-benzenetriol(20), D-mannitol(21), sucrose(22), and β-sitosterol(23). CONCLUSION: All the compounds are isolated from this plant for the first time except for compounds 2, 5, 19, 21 and 23, and from the genus Veronicastrum for the first time except for compounds 2, 5, 6, 12, 13, 19, 21 and 23. The 13C-NMR data of compound 8 is reported for the first time.
ABSTRACT
Objective To study the changes and clinical significance of serum kalium,natrium,chlorine,calcium and glucose in children with febrile convulsion(FC).Methods Serum kalium,natrium,chlorine,calcium and glucose concentrations were measured in 41 children with FC(FC group),30 children with fever and without convulsion(fever group) and 30 normal children(normal group) by automatic biochemical detector.Results Serum kalium and calcium concentrations had no significant difference between FC group and fever group,but they were significantly lower than those of normal group(F=5.965,3.048 P0.05).Conclusions There are hyponatremia,hyperglycemia and lowered blood kalium and calcium in patients with FC.Hence,while treating the patient with FC,the disturbance of blood electrolytes and glucose need be corrected to avoid the recurrence of FC and the progressive injury of important organs such as brain.