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Objective:To study the clinical characteristics, diagnosis, treatment and rehabilitation of auditory agnosia after stroke. Methods:Four stroke inpatients with auditory agnosia as the first symptom from January, 2016 to August, 2018 were reviewed. Results:All the patients started with auditory impairment, followed with motor dysfunction and speech impairment. They had a previous history of cerebrovascular disease once or more, and were finally diagnosed as auditory agnosia after stroke. After comprehensive rehabilitation treatment, all the patients could walk independently, and the activities of daily living were improved. Some patients could discriminate environmental sound, but still were poor in listening comprehension. Conclusion:Post-stroke auditory agnosia is rare, with poor outcome, which needs comprehensive assessment, speech perception training and non-verbal communication training to improve the communication.
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Objective:To observe the effect of melodic intonation therapy combined with speech training on nonfluent aphasia after stroke, and the changes of brain function. Methods:From March, 2017 to August, 2019, 40 patients with nonfluent aphasia after stroke were randomly divided into control group (n = 20) and intensive group (n = 20). Both groups accepted routine speech training, and the intensive group accepted melodic intonation therapy in addition. They were assessed with China Rehabilitation Research Center Chinese Standard Aphasia Examination before and four weeks after treatment. Three patients from each group were examined with resting-state functional magnetic resonance imaging to observe the changes of regional homogeneity (ReHo) of cerebral hemisphere. Results:The scores of comprehension (noun, verb and sentence), repetition (noun and verb), read (noun) and naming (verb) increased in the control group (t > 2.221, P < 0.05), while it increased in comprehension (noun, verb and sentence), repetition (noun, verb and sentence), reading (noun and verb) and naming (noun and verb) in the intensive group (t > 2.179, P < 0.05). The scores of repetition (noun and verb) increased more in the intensive group than in the control group (t > 2.299, P < 0.05)， and the scores of reading (sentence) increased somehow. The ReHo in left cerebellum and temporal occipital area increased and the ReHo in bilateral frontal and temporal cortex decreased after treatment. Conclusion:Melodic intonation therapy based on speech therapy can promote the recovery of speech function for patients with nonfluent aphasia after stroke, especially in sentence reading and words repetition. The changes of the ReHo in resting state may associate with the neurological repairment after brain injury.
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Objective: To evaluate the polyphenol extracted from Litchi chinensis and quantify the content of four kinds of polyphenol therein, the combination of fingerprint and quantitative analysis of multi-components by single marker (QAMS) was used. Methods: A total of 22 batches of extract from Litchi chinensis were assayed by RP-UPLC to establish a common mode of fingerprints. For achieving QAMS, a method was developed by selecting epicatechin as internal reference and the relative correction factor of the three components, procyanidin A2, procyanidin B2, and epicatechin-(4β→8,2β→O→7)-epicatechin-(4β→8)-epicatechin (PC-C), to determine their contents. The feasibility and accuracy of QAMS were evaluated by comparing the contents of four polyphenols determined with two different methods, QAMS and external standard method. Results: Nineteen common peaks were identified in the characteristic fingerprint, nine components, including the known principal components, procyanidine B2 (peak 6), epicatechin (peak 8), PC-C (peak 9), procyanidine A2 (peak 15), three trimers of procyanidine type A (peaks 12, 16, and 17), a dimer of procyanidine type A (peak 19) and a dimer of procyanidine type B (peak 14), were verified in 22 batches of Litchi chinensis extract. Good similarities with correlation coefficients higher than 0.9 were found in 22 batches fingerprints. There was no significant difference between calculated value and detected value of the four ingredients in 22 batches, by QAMS and external standard method. Conclusion: The results showed that the combined method of fingerprint and QAMS for quality control is accurate and feasible and provide reference method to evaluate the quality of extracts from Litchi chinensis.
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Objective: To study the effect of gait analysis based on digital video and digital image processing in rehabilitation training in patients with stroke. Methods: Twenty patients with unilateral hemiplegia after stroke were selected. Gait analysis by digital video and digital image processing were used to evaluate the parameter changes of the temporal-spatial parameters of bilateral limbs (stride circles, stride length, stride frequency, stride speed, stand phase time) and the joint (hip, knee, ankle joints) angles before and after (3 months) the rehabilitation training. Results: Circled digit oneThe stride length and speed in 20 patients were 0.51 ± 0.12 m and 0.26 ± 0.17 m/s before the rehabilitation training; they were 0.66 ± 0.23 m and 0.33 ± 0.21 m/s after the training (P < 0.05 all). There were no significant differences among the stride circles, stride frequency, and stand phase time before and after the training. Circled digit twoThe flexion angle of the affected ankle joint reduced significantly when first touched ground after the rehabilitation training as compared to that before the training; the maximum extension angle of the standing phase of ankle and hip joints was increased; the flexion angle of knee joint increased at toe-off, so did the extension angle of ankle joint; the maximum flexion angles of knee and hip joints at stride phase was increased; the range of hip joint angle change in sagittal plan was increased, and that of the ankle joint angle was decreased. Before and after the rehabilitation training on the unaffected sides, there were no significant changes in other joint angle parameters, except the increased maximum flexion angle of the knee joint in stride phase (P < 0.05). Conclusion: The gait analysis base on digital video and digital image processing contributes to qualitatively evaluate the gait characteristics and the efficacy of rehabilitation treatment in patients with stroke.
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@#Because of the population aging,the increase of the stroke patients and the need for rehabilitation,the treatment only in the rehabilitation department of the hospital is far from the satisfaction of people's demands of the service of rehabilitation.It is important to extend the community-based rehabilitation.Compared with the rehabilitation in hospitals,it is more economy,efficiency and convenience for stroke patients in community-based rehabilitation services,and further improve the rehabilitation effect of stroke patients.
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@#ObjectiveTo study normal gait characteristics of healthy adults in different age groups.Methods90 healthy adults were divided into three groups according to their ages. It was 20～39 year group, 40～59 year group and 60～70 year group. They received a gait analysis with the gait analysis system based on digital video and image processing which could provide temporal-spatial parameters and kinematic parameters. The gait data of the three groups were compared. Relationships between gait speed and other gait parameters were investigated.ResultsThere were statistically significant differences in some parameters among three groups. Gait speed was significantly correlated with stride time, stride length, stance time (%), cadence, maximum flexion of hip and knee in swing phase.ConclusionThe normal gait patterns of healthy adult established with the gait analysis system based on digital video and image processing can be used as the base line to compare with abnormal gait.
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@#ObjectiveTo explore the effect of variable hip abduction orthosis on children spastic cerebral palsy.Methods5 children with spastic diplegia cerebral palsy had used variable hip abduction orthosis to correct scissors gait which remained after rehabilitation. The stepping of 5 children was assessed with a gait analysis system base on digital video and image processing which could provide distance rate between knees and hips(K/I) in gait phase. One year Follow up was carried out.ResultsThere was significant difference on K/I before and after using variable hip abduction orthorsis (P<0.05).ConclusionThe variable hip abduction orthorsis can inhibit adductor muscles convulsion, improve model kinesis of scissors gait and stabilize stepping.