ABSTRACT
Objective To analyze the clinical efficacy of desloratadine citrate disodium and fexofenadine in the treatment of refractory urticaria . Methods 100 patients with refractory urticaria were randomly divided into observation group and control group according to the digital table method, with 50 cases in each group.The control group were treated with desloratadine citrate disodium, and the observation group were treated with fexofenadine on the basis of control group.The efficacy, immunity function ( CD3 +, CD4 +, CD4 +/CD8 +) , the changes of inflammatory factors [ procalcitonin ( PCT) , C-reactive protein ( CRP) ] and the quality of life were compared between the two groups.The adverse reaction rate in two groups was recorded in two groups.Results The total efficacy in observation group (88.0%) was significantly higher than that in control group (72.0%)(P<0.05).The indicators of immunity function in observation group were significantly higher than those in control group(P<0.05).The inflammatory factors in observation group were significantly lower than those in control group ( P<0.05 ) .The sleep and exercise quality rate of the observation group were significantly higher than those in control group(86.0% vs.68.0%,84.0% vs.66.0%,P<0.05).Conclusion The combination of desloratadine citrate disodium and fexofenadine in the treatment of refractory urticaria has a good effect, can effectively improve the immune function, reduce the secretion of inflammatory factors, thus effectively relieve the clinical symptoms, improve their quality of life, and has high security.
ABSTRACT
Objective To investigate the effect of the isotretinoin combined with Dazhui acupoint bloodletting in the treatment of adolescent acne.Methods78 patients with adolescent acne from department of dermatology in our hospital were selected and randomly divided into the control group and the experiment group,39 cases in each group.The control group were treated by isotretinoin and the experiment group were treated on the base of the control group with Dazhui acupoint bloodletting.The clinical total effective rate, incidence of adverse reactions and recurrence rate after 6 months were compared between control group and experiment group.ResultsCompared with the control group after treatment, the clinical total effective rate were higher(P<0.05), the incidence of adverse reactions were lower(P<0.05), the 6 months after the recurrence rate of acne were lower(P<0.05).ConclusionThe application of different dimension an acid combined with Dazhui acupoint bloodletting treatment can improve the adolescent acne clinical total efficiency, reduce the incidence of adverse reaction rate and recurrence rate, and suitable for clinical, it is worth popularization and application.
ABSTRACT
Objective To measure the expressions of HSP10 and 60 in cutaneous squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and solar keratosis (AK) tissue. Methods Lesion samples were resected from patients with SCC (n = 50), BCC (n = 50) and AK (n = 50), and control samples were obtained from the normal skin adjacent to the operation sites of 14 of the 50 patients with SCC, BCC and AK. Immunohistochemical Envision two step method was used to detect the expression of HSP60 and 10 in the tissue samples.Results The expression of HSP10 was significantly higher in BCC tissue samples (Z = 3.24, P ＜ 0.001 ), but not in AK (Z= 0.74, P＞ 0.05) or SCC (Z= 0.52, P＞ 0.05) tissue samples than in the normal control tissue samples. Statistical significance was observed in the expression of HSP10 between AK and SCC and between AK and BCC tissue samples (both P ＜ 0.05), but not between SCC and BCC tissue samples (P ＞ 0.05 ). Elevated expression of HSP60 was found in AK, BCC and SCC tissue samples compared with the control samples (Z =-2.90, -2.15, -2.78,P ＜ 0.01, 0.05 and 0.01, respectively). Furthermore, the expression of HSP60 in SCC tissue samples was higher than that in BCC tissue samples (P ＜ 0.05 ) but similar to that in AK tissue samples. Conclusions There is likely to be a correlation between the high expression of HSP60 and biological behavior of SCC, and between the elevated HSP60 and HSP10 expressions and BCC initiation and development.