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Objective To evaluate the efficacy of ginkgo biloba extract injection combined mecobalamine treatment of diabetic peripheral neuropathy.Methods CNKI, CBM, VIP, Wanfang, PubMed, Cochrane library and Google academic search and other databases were searched, the RCT related ginkgo biloba extract injection combined mecobalamine treatment of diabetic peripheral neuropathy were collected.Meta analysis, drawing forest map and funnel plot by using Rev.Man 5 software.Results A total of 21 RCTs involving 1745 patients were obtained, 905 cases in experimental group and 840 cases in control group.Meta analysis showed that the total effective rate of the experimental group was better than that of control group ( RR=1.40, 95%CI:1.31-1.48), the conduction velocity of motor nerve median nerve(MD=5.39, 95%CI:3.90-6.87), common nerve(MD =5.33, 95%CI:3.82-6.83), sensory nerve median nerve (MD =4.31, 95%CI: 2.89-5.74)and common nerve (MD =4.10, 95%CI: 2.67-5.54)in experimental group were better than those of control group, the difference was statistically significant (P<0.05).Conclusion Ginkgo biloba extract injection plus cobalt-amine peripheral neuropathy in patients with diabetes treatment RCT design flaws, affecting the results of the authenticity and reliability; ginkgo biloba extract injection combined mecobalamine can improve the clinical efficacy and improve nerve conduction speed;due to less number of included studies, research quality is not uniform, still need to carry out more high quality randomized controlled trials to further validate the results.
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Objective To explore the hospitalization costs of patients with diabetic foot ulcer and analyze key influencing factors.Methods A total of 570 diabetic foot inpatients were recruited from January 2008 to March 2012 for analysis of the relationship between their hospitalization costs and clinical symptoms.The multifactor regression analysis model was used to identify main influencing factors for their hospitalization costs.Results The medical costs of such inpatients amounted to 1 9 825.6 yuan (12 476.6~32 745.9)yuan,while average hospitalization costs of the 3 401 diabetic patients admitted over the same period were but 9 757.1 yuan (6 282.1 ~ 1 5 723.7 )yuan,a difference of statistic significance.The single-factor analysis found statistical differences from the differences of hospitalization among various age,occupation,dorsal artery of foot,B ultrasound of lower extremity arteries,wagner classification,amputation,transfer,leucocyte,hemoglobin,serum albumin,serum creatinine and high density lipoprotein.Multifactor analysis found that the significant factors influencing the medical costs of inpatients were days of stay,albumin,wagner classification,dorsal artery of foot,leucocyte and age. Conclusion Hypoalbuminemia,high stage of wagner classification,weak or absent pulsation of foot dorsal artery,severe infection and aging were significant factors contributing to higher medical costs of hospitalization for patients with diabetic foot ulcer.
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Objective To study the regulation of iodine solution dissemination through the portal vein duo to compression of liver tissue in SD rat models.Methods SD rats were divided into three groups:liver segment blocking group,non-liver segment blocking group and placebo group.Right anterior segments of liver were blocked by blocking ribbon before the compression of liver tissue in liver segment blocking group,the liver tissue was pressed in 20 times.The procedures were all the same with blocking groups in non-liver segment blocking group except that the liver tissue is free from blocking.Placebo group only was opened and closed the abdomens.The iodine solution was injected into the liver tissue in right anterior segments and iodine ball should be confirmed under the X-ray in every experimental rats.The severity of the iodine predations in the liver was divided into four degree:Degree A indicated the iodine ball was in situ;no predations;Predations were in right anterior segments only in degree B;Degree C was found iodine spots in other liver segments except right anterior segments;Degree D indicated iodine spread to other organs.The iodine balls were pressed under the pressure between 10 and 15 mm Hg.Results Majority of iodine balls(36/45,80%)were formed successfully in liver tissues.Compression of the iodine balls in liver tissues can cause iodine predations in the vessels in liver.The severity of the dissemination was related to the pressure and the range of the pressings.The blocking of the liver segments before the operation can reduce the predations of iodine.Conclusion Pressing of the liver tissue can caused the iodine balls disseminate in vessels,cancer cells or cause thrombus disseminate in the vessels,Which can be reduced by avoiding the compression of the liver or tumom during the operation.
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BACKGROUND:To introduce the scanning technique and imageologieal signs of multi-slice spiral CT angiography in the diagnosis of venous thromboembolism,and concomitantly evaluate its apphcadon value and advantage in the early diagnosis of venous thromboembolism.METHODS:Using the terms"venous thromboembolism,pulmonary thromboembolism,CT angiography",the authors computer-retrieved Medline to identify studies published between January 1998 and October 2007 in the English language.At the same time,we searched the Wanfang database with the same terms in the Chinese language by hand and computer forstudies between January 2000 and October 2007.A total of 228 manuscripts Were obtained,and 24 of them corresponded to the inclusive criteria.RESULTS:Using collection technique and in conjunction with high-quality three-dimensional reconstructed images,multi-slice spiral CT can clearly reveal the distal branches of pulmonary artery,achieving subsegmental-level diagnosis of Duhnonary thromboembolism.There was no remarkable difference in the sensitivity for diagnosing pulmonary thromboembolism between thin-slice spiral CT and pulmonary artery angiography.The sensitivity and specificity of thin-slice spiral CT is higher compared to pulmonary ventilation-perfusion radioisotope scanning.When eliminating acute pulmonary thromboembolism,spiral CT is a promising first-ehoicemethod.CONCLUSION:Spiral CT is characterized by rapid scanning,clear image,and without omission of small foci.Spiral CT angiography is a safe,rapid,non-invasive,and effective method for the diagnosis of venous thromboembolism.
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<p><b>OBJECTIVE</b>To discover and identify differentially expressed genes associated with colorectal adenoma formation and the role of RegIV in colorectal adenoma differentiation.</p><p><b>METHODS</b>A subtracted cDNA library was constructed with cDNAs that were isolated from either the normal mucosa or adenoma tissue of a single patient. Suppressive subtractive hybridization (SSH) combined with virtual northern blotting was used to characterize differentially expressed genes and contigs were assembled by electronic cloning (in silico cloning) with the EST database. Semi-quantitative RT-PCR was performed in 9 colorectal adenomas.</p><p><b>RESULTS</b>The amino acid sequence was determined with open reading frame (ORF) prediction software and was found to be 100% homologous to the protein product of RegIV (a novel gene isolated from a large inflammatory bowel disease library). RegIV was found to be highly expressed in all of the adenoma samples (9/9) compared with the normal mucosa samples, while 5/6 cases showed RegIV to be more strongly expressed in adenocarcinoma.</p><p><b>CONCLUSION</b>RegIV may play an important role in the initiation of colorectal adenoma differentiation, and its detection may be useful in the early diagnosis of colorectal adenoma formation.</p>
Subject(s)
Humans , Adenoma , Genetics , Metabolism , Blotting, Northern , Colorectal Neoplasms , Genetics , Metabolism , Lectins, C-Type , Genetics , Nucleic Acid Hybridization , Pancreatitis-Associated Proteins , Prognosis , Reverse Transcriptase Polymerase Chain ReactionABSTRACT
Guanylin family, described in recent 10 years, is a series of small peptides (including guanylin, uroguanylin and lymphoguanylin) with structural and functional similarities to heat-stable enterotoxins (STs) elaborated by various pathogenic bacteria. They are abundance of cysteines and are endogenous activators of guanylyl cyclase-C (GC-C) receptors. Immunoreactive guanylin family peptides are localized in many human organs and tissues, especially in gastrointestinal tract and kidney, and play an important role in regulation of water and salt homeostasis. Recent studies showed that the mRNA levels of guanylin family peptides were down-regulated in colorectal cancers; oral intake of uroguanylin might suppress polyp formation in Apc(Min/+) mouse, and ~(111)In-labeled-ST peptide analog might specifically target human colon cancers. These evidences highlight that guanylin family may have a potential application in diagnosis and therapy effects of colorectal cancers.