ABSTRACT
OBJECTIVE:To observe the clinical short-term efficacy and safety of brucea javanica oil injection combined with oxaliplatin and xeloda in the treatment of elderly patients with advanced gastric cancer. METHODS:82 elderly patients with ad-vanced gastric cancer were randomly divided into control group and observation group. Control group was treated with Oxaliplatin injection 130 mg/m2 added into 5% Glucose injection 250 ml for 2 h,iv,d1+Xeloda tablets 1 000 mg/m2,orally,twice a day, d1-14;based on the treatment of control group,observation group was additionally treated with 10% Brucea javanica oil injection 30 ml added into 0.9% Sodium chloride injection 250 ml,iv,once a day,d1-14. 21 days were as a treatment course,and it lasted 3 courses. The short-term efficacy,life quality and toxicity reactions were evaluated in 2 groups. RESULTS:The short-term efficacy in observation group was significantly higher than control group,life quality was significantly better than control group,and the in-cidences of leucopenia and liver damage were significantly lower than control group(P<0.05). CONCLUSIONS:Brucea javanica oil injection combined with oxaliplatin and xeloda has better efficacy than oxaliplatin combined with xeloda in the treatment of elder-ly patients with advanced gastric cancer,with good safety.
ABSTRACT
Purpose:To investigate the choice of surgical therapy for the pancreaticoduodenal region invaded by or involved in stomach carcinoma. Methods:51 patients from Jan. 1981 to Dec. 2000 with stomach carcinoma invaded by or involved in the pancreaticoduodenal region were analyzed retrospectively. Results:All patients were primary stomach carcinoma, the operative methods of stomach carcinoma included subtotal gastrectomy (Group SG,n=29), radical Pancreaticoduodenectomy (Group PD,n=11),gastrojejunostomy (n=8) and tumour’s biopsy (n=3). In group PD, one-,and three-year survival rates was 63.6% and 36.4%, in group SG, it was 17.2% and 3.4%. The survival rate of group PD was markedly better than that of group SG respectively (P