ABSTRACT
Objective To explore the efficacy of partial splenic embolization (PSE) in the treatment of hypersplenism secondary to liver cirrhosis using Meta-analysis.Methods Randomized control studies,cohort studies and case-control studies concerning the efficacy comparison of PSE and splenectomy in the treatment of hypersplenism secondary to liver cirrhosis were searched on PubMed,Embase,Cochrane Library,Wanfang data,CNKI,Cqvip and CBM for Meta-analysis.The cut-off time for searching was July 25,2015.RevMan software designed by Cochrane cooperation network was used for statistical analysis.The major outcomes indexes were preoperative and postoperative levels of platelet,leukocyte and hemoglobin.The secondary outcomes indexes were operative time,intraoperative bleeding and hospital stay.Results A total of 10 studies were selected.Meta-analysis showed the levels of platelet (mean difference [MD]-87.68,95 ％ CI [-125.70,-49.65]),leukocyte (MD-4.03,95％CI [-5.74,-2.33]) and hemoglobin (MD-0.79,95％CI [-1.48,-0.11]) after PSE treatment were higher than those before,and the levels of platelet (MD-128.31,95％CI [-162.59,-94.03]),leukocyte (MD-5.22,95％CI [-6.65,-3.80]) and hemoglobin (MD-1.42,95％CI [-2.66,-0.18]) after splenectomy were higher than those before the operation.The differences of platelet (MD 54.45,95％CI [37.60,71.30]),leukocyte (MD 1.71,95％CI [-0.01,3.42]) and hemoglobin (MD 0.78,95％CI [-0.01,1.56]) between postoperative and preoperative levels for PSE was lower than those for splenectomy.Compared with splenectomy,PSE exhibited less intraoperative bleeding (MD-71.33,95 ％ CI [-78.13,-64.54]),shorter operative time (MD-34.08,95％CI [-34.78,-33.38]) and shorter length of stay (MD-5.59,95％CI [-7.38,-3.79]).Conclusion PSE is a mini-invasive therapy,which can be used to effectively treat hypersplenism secondary to liver cirrhosis.
ABSTRACT
Dihydroartemisinin is an important derivative of artemisinin. We used dihydroartemisinin as the starting material, through esterification, amination and acylation, a series of novel piperazine-sulfonamide contained dihydroartemisinin derivatives were firstly synthesized and their chemical structures were confirmed by IR, 1H NMR, 13C NMR and HR-MS. X-diffraction was used to determine the final configuration of the compound 3c. And the in vitro anti-HeLa activities of compounds 3 were analyzed with CCK-8 method. The preliminary bioassay test shows that compound 3 showed the best inhibition activities against HeLa with IC50 values of 0.14 micromol x L(-1).
ABSTRACT
Objective To assess the predicting value of homocysteine ( HCY), low density lipoprotein cholesterin (LDL-C) and carotid intima-media thickness (IMT) for women with coronary artery disease (CAD). Methods To choose 115 patients with CAD and 102 patients of non-CAD;Homocysteine, LDL-C and IMT were assayed respectively;comparison and correlation analysis were performed based on genders. Results The rates for hyperhomocysteinemia and High Lipoproteinaemia in female CAD patients are 59. 6% and 75.0%,respectively,while they are 69. 9% and 78.6% for male CAD patients,which are both remarkably higher than 23.0% ,26.7%, 22. 2% and 23.6% in non-CAD patients ( Ps ＜ 0. 05 ). ROC curve shows that the best diagnostic boundary point is 0.953 mm for female IMT and 1. 021 mm for male IMT. At the boundary point,the sensitivity,specificity,positive predictive value and negative predictive value are 83.7% ,91.4% ,95.7% and 63. 8% in female, much higher than 62.9%, 65.3%, 76.2% and 53.3% in male. Conclusion hyperhomocysteinemia, high lipoproteinaemia are the important risk factors for women with coronary artery disease;IMT might be used as the predictor of CAD, which have more advantages for female than for male patients.