ABSTRACT
Objective To explore the influence of carbamazepine on the plasma homocysteine (Hcy),folic acid and vitamin B12 levels in the treatment of epilepsy.Methods The clinical medical history and medication com-pliance of 80 epilepsy patients were retrospectively analyzed.40 cases treated with carbamazepine were set as group A,another 40 cases without taking antiepileptic drug therapy were set as group B.And 40 cases in the same period in hospital physical examination were selected as control group.The levels of blood Hcy,folate and vitamin B12 were detected by using the fluorescent quantitative method,the electrochemical luminescence immunoassay,and the differ-ences of three groups of the levels were compared.Results The Hcy level of group A was significantly higher than the control group and group B(F =7.16,P =0.00),and the folic acid level of group A was significantly lower than the control group and group B(F =9.67,P =0.00).The Vit B12 concentration of group A was lower than the control group and group B,but among the three groups,the difference was not statistically significant(F =1.05,P =0.15). Loss of appetite and body weight decreased in 4 cases,2 cases of dizziness,fatigue,but symptoms were mild,did not affect the findings.Control in 13 cases,12 cases were markedly effective,effective in 8 cases,ineffective in 7 cases,the total effective rate was 82.5%.Conclusion Carbamazepine treatment can cause epilepsy patients blood Hcy level rise,and folic acid level drop,has no significant effects on the Vit B12 concentration,so in patients with epilepsy should pay attention to monitor blood Hcy and folic acid level during the treatment,in order to avoid adverse events such as thrombosis and influence the prognosis.
ABSTRACT
Objective:To investigate the effect and safety of Jinweitai combined with triple therapy in the treatment of gastric ul-cer. Methods:Totally 140 cases of gastric ulcer patients were randomly divided into two groups, group A was given clarithromycin, amoxicillin, bismuth pectin and pantoprazole in Hp eradication triple therapy, while group B was additionally given 0. 3g Jinweitai oral-ly, po,tid. The treatment course was 8 weeks. The effect was observed and compared. Results:Both the total effective rate and Hp e-radication rate of group B were higher than those of group A, the rate of mild inflammation and non-neutrophils infiltration after the treatment in group B were higher than those in group A (P0. 05). Conclusion:Base on the conventional Hp eradication triple therapy, Jinweitai can increase Hp e-radication rate and promote inflammation eliminate without extra adverse reactions in the treatment of gastric ulcer.