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Objective To study the effects of DMF on the quality of spermatozoa and sex hormone levels in male mice,and the possible mechanism. Methods Forty male KM mice were randomly divided into four groups and then treated with DMF dissolved in distilled water by gavage (10 ml/kg) at the doses of 0,0.5,1 and 2 g/kg,once a day for 30 consecutive days. The mice were weighted and then sacrificed on day 31. The epididymises were collected for determination of sperm motility,sperm counting and determination of abnormal sperm rate. The T,LH,and FSH levels in serum were determined. Results Compared with the control group,mice in all treated groups showed significant decrease in body weight (P
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0.05). Comparing with 1/8 LD50 MDI group,all 1/16 LD50,1/32 LD50 MDI and the control group were significantly higher in testis coefficient (P
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N, N-dimethylformamide (DMF) is a kind of organic compound which is widely used in the modern industry. With the increasing utilization of DMF year by year, the interest in the research of DMF toxicity has increased dramatically. The data of animal experiments and epidemiological investigations show that DMF has harmful effect on reproductive function of human and animals. The effect of DMF on the reproductive function of animal and occupational crowd were reviewed in this paper, the research perspective was also presented.