ABSTRACT
OBJECTIVE: To investigate the perioperative application of antibacterials in our hospital.METHODS: The application of antibacterial drugs in 142 surgery patients sampled randomly from our hospital in 2006 was investigated in respect of the variety of drugs,medication time and drug combination etc.RESULTS: 100% of the total 142 cases received antibacterials for prophylaxis purpose for 6.8 days on average.58 cases(40.8%) received antibacterials before operation,8 cases(5.6%) during operation and 76 cases(53.5%) after operation.35.8% were rational on the whole and 64.2% irrational in drug use.CONCLUSIONS: The application of antibacterials in our hospital is worrisome,therefore,it is urgent to tighten control on the clinical application of antibacterials.
ABSTRACT
OBJECTIVE: To establish an HPLC method for the determination of Quercetin in Duizuoye tablet. METHODS: HPLC analysis was carried out on Dikma-ODS C18 column (250 mm?4.6 mm, 5 ?m) with methanol-0.4% phosphoric acid solution(53∶47) as mobile phase at a flow rate of 1.0 mL?min-1; the detection wavelength was set at 370 nm and the column temperature was maintained at 35 ℃. RESULTS: The calibration curve for Quercetin was linear in the range of 1.31～9.17 ?g?mL-1 (r=0.999 8).The average recovery was 98.06%, with RSD of 1.05% (n=6).CONCLUSION: The adopted method is simple, rapid and accurate, and suitable for the quality control of Duizuoye tablet.