Polymorphism of bone morphogenetic protein receptor-IB [BMPR-IB] gene with litter size and kids growth of some goat breeds in Egypt

Polymerase Chain Reaction-Restriction Fragment Length Polymorphisms [PCR-RFLP] and Single Nucleotide polymorphism [SNP] techniques were used to study the association between bone morphogenetic protein receptor IB [BMPR IB] gene polymorphism with litter size trait and kids growth. Forty four Female goats were precisely selected according to their litter size and kids growth. PCR amplification of 190 bp of the BMPR-IB gene was genotyped in all goats and sequenced only in those produced the highest and lowest litter size and kids growth. Restriction analysis of PCR-RFLP using Ava II and Hind III of the BMPRIB gene [190-bp] do not produce restriction fragments. By DNA sequencing, eight single nucleotide polymorphisms [SNP's] at seven different positions were obtained. Furthermore, with translation of SNPs to corresponding amino acids, change of six amino acids in three female goats were obtained as the following, Baladi goat with high litter size, glutamic acid [E] changed to aspartic acid [P] and isoleucine [I] changed to valine [V]. In high litter size, Zaraibi goat, valine [V] changed to leucine acid [L] and glutamine [Q] changed to histidine [H] and threonine [T] changed to proline [P]. These findings can be used in a marker-assisted selection [MAS] for selection for high litter size trait in goats. There are negative relationships in most goats between SNPs in BMPR IB gene and relative growth gain [RGG]

[Klippel trenaunay weber syndrome: a case report]

The Kippel Trenaunay Weber syndrome is a rare entity. It is characterized by osteohypertrophic angiodysplasia. The vascular abnormalities touch especially the lymphatic and venous systems. However the existence of superficial or deep arteriovenous fistula is not rare. The deep one can have multiple visceral seats and put a strain on vital prognosis of patients in the event of a rupture. The authors report the case of a 9 year-old girl who presented a Klippel Trenaunay Weber Syndrome diagnosed on the occasion of a recurrent rectorrhagia which lead to severe anemia with 4,4g/100 ml of haemoglobin. The osteohypertrophic angiodysplasia touch the two inferior limbs. It is more marqued on the right side and extends to the lumbus. The colonoscopy found a rectosigmoidal fistula associated with a rectal prlapsus. The abdominal angioscan found multiple parietointestinal calcifications. It shows that vascular abnormalities in digestif tractus are diffuse. In the light of this case and the review of literature, the authors remind the clinical, para clinical aspects and difficulties of treatment of this rare entity

[Cystic adenomatoid malformation involving an entire lung in a 16-month-old girl]

Congenital cystic adenomatoid malformation [CCAM] is a congenital uncommon anomalie. It represents 25 per cent of congenital malformations of the lung. Usually discovered before the age of 2 years, it's often known while infectious complications after year of life. The lesion is usually unilateral, and unilobuloar. The surgical resection will lead to a histologic study that can confirm the diagnosis and establish a final classification of the lesion. In this subject, we present the case of 16 months old girls that had a CCAM occupying the whole left lung and that was discovered while an episode of pneumonia. Outcome was good after total left pneumonectomy