Diabetic nephropathy with inflammatory indicators [IL-1B, IL-6, IL-8, CRP]

cytokines production is associated with diabetes mellitus and in its turn is associated with infiltration of the islets of Langerhans with autoreactive lymphocytes and specific destruction of the insulin-producing B cells. Our aim is therefore to investigate the effect potential role of the effect of the cytokine especially [interleukin-lB, interleukin-6, interleukin-8] and C-reactive protein [C.R.P.] on the microvascular complications of diabetes [nephropathy]. A total of 31 diabetic patients with nephropathy aged 45 to 60 years, undergoing dialysis were compared with non-diabetic control subjects [N=20] after matching for age and sex, and were compared also with diabetic subjects without nephropathy [N=124]. Immune parameters were analyzed in serum with rigidly evaluated ELISA. Serum proinflammatory interleukin-6 [IL-6] and interleukin-8 [IL-8] concentrations were higher in nephropathy diabetic patients than in the control subjects [Mean for IL-6 in nephropathy and control subjects 6.9 Pg/ml, 1.2 Pg/ml respectively P

Interleukin-6 and its relationship with the complications of diabetes millitus

Diabetes mellitus is a complex disease with multiple complications which classified to two categories: Acute complications: Hypoglycemia, diabetic ketoacidosis [D.K.A] and hyperglycemic hyperosmolar non ketonic syndrome [H.H.N.K]. Chronic complications: Macrovascular complications, Microvascular complications, diabetic Retinopathy, diabetic Nephropathy and diabetic Neuropathy. We evaluated the relationship of proinflanimatory cytokines [IL-6] with microvascular complications of diabetes mellitus. The first group included [31] diabetic nephropathy patients [dialysis patients]. The second group included [67] diabetic patients with retinopathy. The third group included [57] diabetic patients with neuropathy. The three groups compared with control group included [21] healthy subjects absence of any systemic diseases and infections, matched for sex and age. Our results showed significant increase in both mean plasma glucose and [[p<0.05]. The renal patients group were compared with control group and the correlation between high [LL-6] levels and incidence of nephropathy was significant. The second group showed significant increase in the mean plasma [IL-6] levels [p<0.05]. x test showed significant correlation between the serum [IL-6] levels in the patients and incidence of retinopathy. Whereas in the third group, our study showed no significant differences in levels of [IL-6] compared with control group [p>0.05] and no correlation between the serum [LL-6] and incidence of Neuropathy