ABSTRACT
Hirsutism is a common problem in young women that may be, sign of internal glands diseases [eg: ovary, adrenal, hypophysis,...]. The aim of this research was measurement of serum level of hormones that produce by these glands in women with hirsutism. In this cross-sectional, descriptive research, in all the hirsute women that referred to Dermatology clinic of Jahrom from April 2004 to April 2005 serum level of Testosterone, Dehydroepiandrosterone-sulphate [DHEA-S], prolactin, Luteinizing hormone [LH] and Follicle-Stimulating Hormone [FSH] was measured with ELISA method. Testosterone > 1.2 ng/ml. DHEA-S > 41 micro g/ml, prolactin > 25 ng/ml and LH/FSH>3 was considered abnormal. Data was analysed by chi-square method. Out of 81 patients who was referreds, 59 patients [72.8%] had positive FHx of hirsutism and 42 pts [52%] had irregular menstruation. Serum testosterone, DHEA-S and prolactin was high in 9.9%[7pts of Vlpts], 12.7% [10pts of 79pts], 10.1% [8pts of 79pts] respectively and 23.8% [19pts of 80 pts] had LH/FSH>3. High level of serum testosterone. DHEA-S and prolactin didn't have significant correlation with irregular menstruation [P=.429, .087, .713 respectively], Positive FHx [P= .67, .452, 1.000 respectively] and marrital status [P=.684, .73, .707 respectively]. LH/FSH>3 had significant correlation with irregular menstruation [P<0.001], But didn't have significant correlation with age [P=0.126], merrital status [p=.784] and positive FHx [P=.648]. Overall 34 pts [42/5%] had at least one abnormality in their laboratory examination [testosterant [up arrow] or DHEA-S[up arrow] or prolactint [up arrow] or LH/FSH >3]. Out of 81 pts, 59 pts [72.8%] had positives FHx of hirsutism so it seems that genetic has significant role for inducing of hirsutism. Many pts with hirsutism [34 pts [42.5%]] had at least one hormonal abnormality so as screening tests, measurement of hormones such as testosterone, DHEA-S, prolactin, LH and FSH is necessary in pts with hirsutism