ABSTRACT
This study aimed at determining the percentage of primary amenorrhea, some epidemiological risk factors, the effect and frequency of chromosomal abnormalities in females with primary amenorrhea. All females complaining of primary amenorrhea, who attended the Outpatient Clinic of Obstetric and Gynecology Department in Zagazig University Hospital through one year from January to December 31, 1990, were studied representing 60 females out of 5392. Another 60 fertile females with regular menstrual cycle were randomly selected as a control group. Their ages ranged from 17 to 40 years. All females were subjected to full general, medical, gynecological and histological [chromosomal], investigations. The results of this study revealed that the percentage of primary amenorrhea was 1.1% out of 5392 females and 36.7% of all amenorrheaic cases had abnormal chromosomal constitution. And 70% of cases had structural chromosomal aberration. On the other hand, anthropometric measurements regarding to height, weight, and span, and congenital anomalies, were related to the occurrence of primary amenorrhea. However, no significant difference was observed with age and marital status. Finally, it is recommended that, genetically determined primary amenorrheic case can be prevented by genetic counseling. Premarital examination and good antenatal care of mothers should be also provided to avoid the risk of congenital malformation