ABSTRACT
Objective To investigate the effect of activity intervention on intestinal cleansing of patients with cervical cancer undergoing oral administration of compound polyethylene glycol electrolyte powder, so as to improve the intestinal cleanliness of patients and reduce the adverse reactions of drugs. Methods A total of 75 cases of cervical cancer patients were divided into intervention group containing 37 cases and control group containing 38 cases by lottery, the control group before taking medicine was given the diet guidance, explaining the method of taking medicine and time of taking medicine, as well as points for attention after taking medication;while the intervention group increased activity intervention on the basis of the control group. Results The intervention group of patients with intestinal cleanlinessⅠ degree accounted for 78.37％ (29/37), Ⅱ degree (18.91％, 7/37) and Ⅲ degree (2.7％, 1/37); while the control group of patients with intestinal cleanliness Ⅰ degree accounted for 55.3％ (1/38), Ⅱ degree (23.7％, 9/38) andⅢdegree (21.1％, 8/38), and the difference was statistically significant (χ2=6.962, P=0.031).The intervention group with nausea and vomiting level 0 accounted for 59.5％ (22/37), level Ⅰ(24.3％, 9/37) and level Ⅱ(16.2％, 6/37); while the control group with nausea and vomiting level 0 accounted for 28.9％ (11/38), level Ⅰ(44.7％, 17/38), level Ⅱ (26.3％, 10/38), the difference was statistically significant(χ2 = 7.116, P = 0.028). The intervention group with abdominal distension level 0 accounted for 62.2％(23/37), level 1(24.3％, 9/37), level 2 (13.5％, 5/37) and level 3 (0);while the control group with abdominal distension level 0 accounted for 28.9％ (11/38), level 1(47.4％, 18/38), level 2 (21.1％, 8/38) and level 3 (2.6％,1/38), the difference was statistically significant (χ2=8.916, P=0.030). The first defecation time of the intervention group was (2.18 ± 0.59) h and the total defecation time was (2.93 + 0.86) h, while the first defecation time of the control group was (3.13 + 0.64) h and the total defecation time was (3.80+1.01) h, and the difference was statistically significant (t=-3.035,-2.520, P<0.01 or 0.05). Conclusion Activity intervention can improve the intestinal cleansing effect of cervical cancer patients and reduce the occurrence of adverse reactions.
ABSTRACT
A fluorescent immunochromatographic test strip based on the quantum dots submicrobeads (QBs) was developed for quantitative detection of chloramphenicol (CAP). In this method, monoclonal antibody of CAP and OBs complex fluorescent probe was first prepared using 1-ethyl-3-( 3-dimethylaminopropyl ) carbodiimide / N-hydroxysuccinimide coupling approach, then complete antigen CAP-HS-BSA was synthesized and sprayed on nitrocellulose membrane as test line (T line). Similarly, goat anti-mouse antibody was sprayed as control line (C line). The time required for the analysis was 15 min, and the limit of detection (LOD) for CAP was 0. 1 μg / L, with a working range of 0. 1 - 100 μg / L. In spiked milk samples, the test strip demonstrated high recoveries in the range from 93. 3% to 97. 9% with relative standard deviations of less than 7% .
ABSTRACT
The objective of this prospective study of the risks of treatment failure in patients with drug-susceptible pulmonary tuberculosis (PTB) was to provide reference data to help develop a disease control strategy. Participants were recruited in eight provinces of China from October 2008 to December 2010. A total of 1447 patients with drug-susceptible PTB and older than 15 years of age were enrolled. Demographic characteristics, bacteriological test results, and patient outcome, i.e., cure or treatment failure were recorded and compared using the chi-square or Fisher's exact tests. Multivariate logistic regression was used to identify factors associated with risk of treatment failure. Of the 1447 patients who were enrolled, 1349 patients (93.2%) were successfully treated and 98 (6.8%) failed treatment. Failure was significantly associated with age 365 years [odds ratio (OR)=2.522, 95% confidence interval (CI): (1.097-5.801)], retreatment [OR=2.365, 95% CI: (1.276-4.381)], missed medicine [OR=1.836, 95% CI: (1.020-3.306)], treatment not observed [OR=1.879 95% CI: (1.105-3.195)], and positive culture result after the first [OR=1.971, 95% CI: (1.080-3.597)] and second month [OR=4.659, 95% CI: (2.590-8.382)]. The risk factors associated with treatment failure were age 365 years, retreatment, missed medication, treatment not observed, and positive culture at the end of month 1 or month 2. These risk factors should be monitored during treatment and interventions carried out to reduce or prevent treatment failure and optimize treatment success.