ABSTRACT
Objective To observe the changes of serum aldosterone(ALD)in children with patent ductus arteriosus(PDA)at before and after interventional therapy,and explore its relationship with cardiac remodeling and its clinical significance.Methods Serum ALD level taken in supine position,left heart chambers sizes and heart f unction in children with PDA were measured and compared before,24 hours part intervention and at 1 month and 3 months after.The relationship between ALD and the left heart chambers sizes and the heart function were analyzed.Results Serum ALD levels were significantly lower 24 hours,1 month and 3 months than the pre-procedure levels [(348.44± 54.27)pmol/L vs.(311.35±50.34)pmol/L vs.(258.14±50.56)pmol/L vs.(199.09±48.12)pmol/L,F=18.98,P＜0.05].The lef t atrial diameter indexes[(42.33±6.44)mm/m2 vs.(36.22±5.33)mm/m2 vs.(35.54±5.36)mm/m2 vs.(34.26±4.32)mm/m2,F=12.18,P ＜ 0.05] and the lef t ventricular end diastolic diameter indexes [(69.34±7.43)mm/m2 vs.(67.43±6.33)mm/m2 vs.(66.35±6.56)mm/m2 vs.(60.54±5.34)mm/m2,F=11.71,P＜0.05] were also lower at 24 hours,1 month and 3 months after intervention than pre-procedure measurements.The left ventricular end systolic diameter indexes measured at 24 hours,1 mouth and 3 mouths after intervention were all lower as compared to pre-procedure condition[(39.43±8.32)mm/m2 vs.(38.47±7.45)mm/m2 vs.(36.85±5.43)mm/m2 vs.(35.63±5.34)mm/m2,F=13.13,P ＜ 0.05].There was relevance between the serum ALD level and the left heart chamber size indexes(P ＜ 0.05).Conclusions Early interventional therapy for PDA can reverse the activation of aldosterone secretion and cardiac remodeling.