ABSTRACT
<p><b>OBJECTIVE</b>To investigate the toxicity attenuation and efficacy potentiation effect of liquorice on treatment of rheumatoid arthritis (RA) with Tripterygium wilfordii (TW).</p><p><b>METHODS</b>One hundred and twenty RA patients were randomly assigned to two groups: the treated group treated with compound decoctum of TW and liquorice and the control group with TW ployglycosidium tablets both based on routine treatment. The therapeutic effect and adverse reaction were observed after 2 months of treatment.</p><p><b>RESULTS</b>The total efficacy rate was 89.8% in the treated group and 79.6% in the control group with insignificant difference between the two groups; the effect was better in the treated group than that of the control group in decreasing the swollen joint index and increasing the average grip strength of both hands (P < 0.05); the total incidence of adverse reaction was obviously lower in the treated group than that of the control (P < 0.01).</p><p><b>CONCLUSION</b>Liquorice has toxicity attenuation and efficacy potentiation effect on treatment of RA with TW.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Arthritis, Rheumatoid , Drug Therapy , Drug Synergism , Drug-Related Side Effects and Adverse Reactions , Drugs, Chinese Herbal , Therapeutic Uses , Glycyrrhiza , Chemistry , Phytotherapy , Tablets , Treatment Outcome , Tripterygium , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To explore the risk factors of nosocomial infection in severe craniocerebral trauma and the way of prevention.</p><p><b>METHODS</b>The clinical data of 387 patients with severe craniocerebral trauma were reviewed.</p><p><b>RESULTS</b>The total nosocomial infection rate of this study was 22.99%. Pulmonary nosocomial infection presented most frequently. The G-bacilli were the most common infectious bacteria. The mortality rate of the infection group was 38.20%.</p><p><b>CONCLUSIONS</b>Complications of nosocomial infection affect the prognosis of craniocerebral trauma patients. Nosocomial infection is related to the age of the patients, craniocerebral trauma severity, unreasonable utilization of antibiotics and invasive operations, such as tracheal cannula, mechanical ventilation, urethral catheterization and deep venous catheterization. Patients with severe craniocerebral trauma should be carefully treated and nursed to avoid nosocomial infection. In order to reduce the rate of nosocomial infection, intensive measurement should be adopted.</p>