ABSTRACT
The pellet-preparating theories and processes of two kinds of methods of extrusion-spheronization and fluid-bed coating method were compared. The micromeritic properties, yield and in vitro dissolution of Danggui Buxue pellets prepared by the two methods were determined. Results showed that the Danggui Buxue pellets prepared by extrusion-spheronization were all spheral with smooth surface, the yield of those pellets was higher and in vitro dissolution of those pellets was more satisfactory. So the two kinds of methods were all suitable to prepare Dang-gui-bu-xue pellets, but Extrusion-spheronization was superior to fluid-bed coating method.
Subject(s)
Chemistry, Pharmaceutical , Methods , Dosage Forms , Drug Compounding , Methods , Drugs, Chinese Herbal , ChemistryABSTRACT
<p><b>OBJECTIVE</b>To study the pharmacokinetics of pueraria flavonoids(PF) from Pueraria lobata.</p><p><b>METHOD</b>An anti-oxidant pharmacodynamics effect method was quoted to detect the antioxidant ability of PF contained in rats plasm after oral delivered, measures the fluorescence intensity, and calculates the concentration of components in plasma, then we can get the plot of the change of the content of PF contained in rats plasm, and then we can get the pharmacokinetics of Pueraria Flavonoids pellets.</p><p><b>RESULT</b>The AUC of Pueraria lobata isoflavone pellets is 4.40-fold of Yufengningxin tablets.</p><p><b>CONCLUSION</b>It can enhance the bioavailability of PF by made it to pellets.</p>