ABSTRACT
Lung cancer is one of the most important malignant tumors in the world. The morbidity and mortality rank the first in all kinds of cancer. Long non-coding RNA (lncRNA) is at least 200 nt long and has no protein coding capacity. It plays an important role in the epigenetic regulation, cell cycle regulation, the regulation of cell differentiation, and many other life activities. The studies indicate that dysregulation of lncRNAs in non-small cell lung cancer (NSCLC) tissue and blood circulation is associated with the occurrence and development of cancer. The lncRNAs play an significant role in proliferation, differentiation, migration and apoptosis of the tumor cells. Explore the potential mechanism between lncRNAs and NSCLC is beneficial for the early diagnosis, target therpy and improve prognosis. Therefore, the study aims to demonstrate the latest studies on the lncRNAs related to occurence, diagnosis, therpy and prognosis of NSCLC. It can help to deeply understanding of lncRNA, and provide new ideas for the prevention of NSCLC.
Subject(s)
Humans , Carcinogenesis , Genetics , Carcinoma, Non-Small-Cell Lung , Diagnosis , Drug Therapy , Genetics , Pathology , Molecular Targeted Therapy , RNA, Long Noncoding , GeneticsABSTRACT
Objective To analyze the data of malignant tumor mortality and change in disease burden in Hebei province from 1973 to 2013.Methods Cancer mortality rate,age-standardized mortality rate and the years of life lost due to premature mortality (YLLs) were calculated by using the data from three rounds of all death causes survey and database of cancer registry in Hebei during 1973-2013.Results From 1973 to 2013,a linear upward of malignant tumor mortality was observed,with a 51.57％ increase.The mortality rate during 1973-1975 was 98.52/100 000 and it was 149.33/100 000 during 2011-2013.During 1973-1975,the YLLs was 17.0/1 000 in males and 12.8/1 000 in females.While during 2011-2013,the YLLs was 23.2/1 000 in males and 15.9/1 000 in females.During 1973-1975,esophagus cancer,stomach cancer and liver cancer were top three leading causes of deaths.During 2011-2013,lung cancer,stomach cancer and liver cancer were main leading causes of deaths.During the past 40 years,the deaths of esophagus cancer and cervix cancer decreased dramatically,but the deaths of lung cancer and breast cancer increased sharply.Conclusions The disease burden caused by malignant tumor is becoming more serious in Hebei.It is necessary to strengthen the primary prevention and screening of malignant tumor.
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Objective To analyze the data of malignant tumor mortality and change in disease burden in Hebei province from 1973 to 2013.Methods Cancer mortality rate,age-standardized mortality rate and the years of life lost due to premature mortality (YLLs) were calculated by using the data from three rounds of all death causes survey and database of cancer registry in Hebei during 1973-2013.Results From 1973 to 2013,a linear upward of malignant tumor mortality was observed,with a 51.57％ increase.The mortality rate during 1973-1975 was 98.52/100 000 and it was 149.33/100 000 during 2011-2013.During 1973-1975,the YLLs was 17.0/1 000 in males and 12.8/1 000 in females.While during 2011-2013,the YLLs was 23.2/1 000 in males and 15.9/1 000 in females.During 1973-1975,esophagus cancer,stomach cancer and liver cancer were top three leading causes of deaths.During 2011-2013,lung cancer,stomach cancer and liver cancer were main leading causes of deaths.During the past 40 years,the deaths of esophagus cancer and cervix cancer decreased dramatically,but the deaths of lung cancer and breast cancer increased sharply.Conclusions The disease burden caused by malignant tumor is becoming more serious in Hebei.It is necessary to strengthen the primary prevention and screening of malignant tumor.
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Objective:To investigate the effects of total flavonoids from Cycas Revolute on expression of vascular endothelial growth factor (VEGF),basic fibroblast growth factor (bFGF),Hypoxia inducible factor-1α (HIF-1α) and nuclear factor-κB(NF-κB) in model mice of Lewis lung cancer.Methods: The expressions of VEGF,bFGF,HIF-1α and NF-κB in tumor tissues were detected by immunohistochemistry and Western blot.The expression of VEGF,VEGF and NF-κB in tumor tissues were detected by fluorescent quantitative PCR.BFGF,HIF-1α and NF-κB mRNA were detected by immunohistochemistry.Results: The results of immunohis-tochemistry,Western blot and Real-time PCR showed that the results were basically the same,compared with model group,the expression of VEGF,bFGF,HIF-1α,NF-κB mRNA and the expression of VEGF,bFGF,HIF-1α and NF-κB were decreased,the difference was highly significant (P<0.05).Conclusion: The mechanism of total flavonoids from Cycas Revolute in the treatment of lung cancer may be through inhibition of the expression of VEGF,bFGF,HIF-1α,NF-κB in invasion and metastasis,and further inhibit the expression of VEGF,bFGF,HIF-1α and NF-κB in invasion and metastasis-related proteins,thus play a role of anti-lung cancer invasion and metastasis.
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Objective To evaluate the influnce of atrial fibrillation(AF)/atrial flutter on the mortality and prognosis of patients with AMI. Methods A total of 297 consecutive patients were studied from Jan.2001 to Dec. 2005 and were categorized into 2 groups according to the presence or absence of AF/atrial flutter. The 30 d and 6 mo mortalities, Killip Grades, cardiogenic shock, arrhythmia and left ventricular ejectory functional (LVEF) 6 months after AMI with Doppler US between the 2 groups were compared. Results The incidence of AF/atrial fluttler was 12.5% with older age, higher Killip Gorade, higher CPK peak, higher rates of previous myocardial infarction and multivascular involvement than those without AF/atrial flutter. The short and medium-term mortalities in AF/atrial flutter group were both significantly higher than those of non-AF/atrial flutter group(P