ABSTRACT
Background: Severe preeclampsia is the main cause of maternal mortality. The correlation between vitamin D and hypertensive disorder of pregnancy is a controversial topic at present. Whether vitamin D can be used as an index to predict the risk of preeclampsia and when to supplement vitamin D in clinic has become a relatively popular research content. This study aimed to correlate vitamin A and D with hypertensive disorder of pregnancy and to reduce the risk of hypertension in pregnancy. Methods: This is a Prospective cohort study on 958 pregnant females. The patients were divided into two groups, namely, treatment group and Pregnancy Induced Hypertension (PIH) group. Liquid chromatography-tandem mass spectrometry and highperformance quid gel electrophoresis were used to find vitamin A and D in the blood of each group (HPLC). Results: There has not been a big difference in between PIH group and the placebo group (p>0.5). Preeclampsia collection and simple preeclampsia group there has been a statistical change in cesarean unit amount and impulsive transfer (p<0.05). The study further found that There is no rise in the likelihood of mild pregnancy complications, and the thing that is different would not be statistically important (p>0.05). Serum vitamin D level is less than 20 ng/ml, which is a risk factor for preeclampsia. Conclusion: The lack of vitamin A may be associated with the occurrence of hypertensive disorders during pregnancy and the progression of the disease. The lack of vitamin A may increase the risk of severe preeclampsia risk increased.
ABSTRACT
Vitamin A is essential for the health of the mother as well as for the health and development of the fetus. Vitamin A deficiency has affected 19 million pregnant women with the highest burden found in the WHO regions of Africa and South-East Asia. Vitamin A is available in multiple vitamin formulations for prenatal care in some countries. When provided alone, the compounds most commonly used are retinyl palmitate and retinyl acetate in tablet form or oil-based solutions. Hypertension is common in pregnancy and causes high maternal mortality. This includes gestational hypertension, preeclampsia, severe preeclampsia, and pregnancy with chronic hypertension. Preeclampsia is a high-mortality disease among the common complication of hypertensive disorder of pregnancy. in particular, severe preeclampsia possess a serious threat to the safety of mothers and children, and there are great difficulties in the treatment of hypertensive disorders of pregnancy during clinical work. therefore, we are adequate in dealing with hypertensive disorders of pregnancy. Any adverse pregnancy outcomes associated with hypovitaminosis D should be accessed through the perspective of immune dysregulation both at the systemic and placental levels. It signifies the supplementation of vitamin D in pregnancy have a role in the improvement of maternal hypertensive complication and improve the fetal outcome.