ABSTRACT
Background: The mortality and morbidity associated with oral Squamous cell carcinoma (OSCC) can be greatly re-duced if tumor markers which can detect OSCC at an early stage are available. This study attempts to use saliva as the diagnostic medium to determine the correlation of salivary CA 125 and LDH in tobacco users with and without potentially malignant disorders. Changes in CA 125 and LDH level can be used as a marker in patients with and with-out premalignant disease and can be used as a deterrent in continuation of the habit. Aims:To assess the role of CA 125 & LDH as a tumour marker in Oral cancer patients. Materials and methods:Cross sectional observational study .Time period: December 2015 to August 2017.Study area: OPD of tertiary care hospital in pune. Total partici-pants: 150 persons. Under non-stimulatory conditions whole saliva sample was collected from each individual and was centrifuged. The resulting supernatant was used for estimation of CA 125 and LDH levels. Results:In present study, mean Salivary LDH level was found to be lowest among cases of healthy individuals while it was highest among individuals who were diagnosed and underwent treatment for malignancy. However there was insignificant difference seen between levels of diagnosed case of oral malignancy and the ones who underwent treatment for oral malignancy. Also mean Salivary CA-125 was lowest in healthy individuals and highest in individuals diagnosed with oral malignancy and the levels were seen to be reduced significantly in the one who underwent treatment for oral malignancies than those who didn’t. Conclusion:Salivary CA 125 and LDH has a role in early detection of oral malig-nancies and can be used as a diagnostic marker. However LDH levels are persistently raised even after treatment for oral malignancy.
ABSTRACT
Background: Ever since HIV was first identified in India among sex workers in Chennai during 1986, HIV infections have been reported in all states and territories. The knowledge and attitudes of healthcare workers (HCWs) in relation to HIV infection is an important factor influencing the willingness and ability of people with HIV to access care, and the quality of the care they receive. Aims & Objective: To assess HIV-related knowledge and risk perception among a group of north Indian health care workers (HCW), and to identify predictors of willingness to provide care for patients with HIV infection. Material and Methods: A cross-sectional survey of 450 HCWs from tertiary health care centre was undertaken in March 2011. The information was collected on a semi structured, self-administered questionnaire. Information was gathered regarding demographic details, HIV-related knowledge, risk perception and previous experience caring for HIV-positive patients. Results: Most (95.7%) were aware of the routes of transmission. 4.1% HCWs wished that they should be allowed to refuse to care for people with HIV/AIDS. HCWs willingness to provide care for patients with HIV was strongly associated with having previously cared for patients with HIV (P = 0.001). Knowledge of HIV transmission and perception of risk were not associated with willingness to provide care (p<0.05). Conclusion: The knowledge of HCW was satisfactory. But periodic updates are required to enhance the knowledge of HCW. These include the development of programmes to promote occupational safety of HCWs and involving people with HIV in awareness training of HCWs.
ABSTRACT
Safety and immunogenicity of Brucella abortus RB51 vaccine has been evaluated in an organised dairy farm in India. All the cattle (n=29) vaccinated with strain RB51 ‘responded’ to the vaccine as demonstrated by iELISA using acetone killed strain RB51 antigen. The percentage responders at day 35, 60 and 90 post vaccination were 100%, 95% and 20%, respectively. Strain RB51 was able to elicit a good IFN- response from vaccinated animals. The post-vaccination time point analysis indicated that the cumulative IFN- response of whole blood from vaccinates stimulated with heat killed RB51 antigen was elicited in 80% of calves at 60 days post vaccination. Absence of strain RB51 in the secretions and excretion and lack of local or systemic reaction indicated the safety of the vaccine.
ABSTRACT
Gagging is a frequent impediment to the performance of dental procedures. This stimulation of the gagging reflex, or more accurately, the vomiting reflex, is a special problem in prosthodontic service. A hypersensitive gagging reflex often prevents the dentist from carrying out critical procedures or causes them to performat a less than satisfactory level. In addition, once having suffered an unpleasant gagging experience in a dentist's office, the patients develop a fear of further visits to dentists. The purpose of this paper is to describe methods of managing the gagging patient that has a sound rationale based on modified treatment approaches starting from impression making to design of the prosthesis aided by training dentures to help the patient to tolerate prosthesis in mouth before fabrication of definite prosthesis.