ABSTRACT
Background: Platelet aphaeresis is an essential procedure, which meets the demand of single donor platelets (SDP) effectively. The procedure is well tolerated by donors with fewer side effects. Adverse events in Platelet aphaeresis have been reported from as low as 0.32 to 6.81%. Aims and Objectives: The aim of present study is to ascertain adverse events observed in a large cohort of platelet aphaeresis procedures and determining management strategies to resolve them. Materials and Methods: This is a retrospective cross-sectional study, from January 2012 to May 2019 in Blood Bank, Department of Pathology, in a tertiary care centre in Central India. Donors for Platelet aphaeresis were selected based on the standard criteria of National Aids Control Organization (NACO) guidelines 2017 and Platelet aphaeresis protocol. Leukoreduced SDP were collected by Haemonetics® MCS +, having Leukoreduction bag system. Adverse events encountered were noted and categorized. Results: A total number of 1600 Plateletpheresis procedures were conducted to prepare SDP and transfused to 1054 patients. A total of 24 out of 1600 plateletaphaeresis procedures reported adverse events (1.5%). Donor related adverse events were 16 (66.6%), Kit related 4 (16.66%) procedure related were 4 (16.66%). Three out of 24 procedures were terminated prematurely, 1 due to severe hypocalcaemia (ACD effect) in donor and 2 due to bowl leakage. Conclusion: Platelet aphaeresis is a safe procedure for donors if done expertly while exercising caution. Adverse events reported are minimal and manageable.
ABSTRACT
Background: Viral hepatitis is a global health problem with 170 million Hepatitis C Virus (HCV) carriers worldwide, and 12-13 million HCV carriers in India. Unscreened blood and components play a significant role in transmission of HCV apart from reuse of injection needles, unsterilized surgical equipments and vertical transmission from mother to child. Unsafe blood transfusion not only poses risk to patients, causing significant morbidity and mortality, but also adds to the economical burden on healthcare system. Aims and Objectives: Aim of this study is to estimate the seroprevalence of HCV infection among the voluntary and relative donors over a period of 7 years at blood banks of Madhya Pradesh with collaboration of Madhya Pradesh State AIDS control Society (MPSACS) Bhopal, India from 2011 to 2017. Materials and Methods: This is a retrospective study of blood donation at blood banks, of Madhya Pradesh, India. Blood units were screened for TTIs from January 2011 To December 2017. HIV, HCV and HBV tests were done by ELISA. Data of HCV was collected and compared statistically by frequency distribution and percentage proportion. Chi Square (? 2) test was used to determine the significant difference statistically. Results: The mean age of donors was 32.4 2 ± 8.63 years. Major contribution was from male donors (93.8%). Majority of donation was done voluntarily (87.3 %). Out of the total 1,876,219 donors tested for TTIs over 7 years, 1980 (0.11%) were positive to anti HCV (p=.000001). Conclusion: The prevalence of HCV infection was 0.11% among blood donors of Madhya Pradesh, with geographic variation among districts. Aiming to provide safe blood to the patients, prevention of transmission of HCV by proper donor counseling and screening of the unit is required.
ABSTRACT
Introduction: A Transfusion transmitted infection (TTI) is a virus, parasite, or other potential pathogen that can be transmitted in donated blood through a transfusion to a recipient. This transmission is one of the most dreaded complications of blood transfusion. Aims and Objectives: The present study is aimed at evaluating the prevalence of TTIs among the blood donors in Madhya Pradesh, a central state of India Materials and Methods: The present five years (1st January 2012 to 31st December 2016) study is a retrospective analysis of one million three hundred thirty-six thousand one hundred fifty-six (1,336,156) blood donor’s record at Madhya Pradesh Aids Control Society (MPSACS) Bhopal; donors donated their blood at National Aids Control Organization (NACO) supported blood banks, Madhya Pradesh, India. With the permission of MPSACS, donor’s data was collected, retrieved, tabulated, summarized and compared statistically by frequency distribution and percentage proportion. Chi-square (X2) test was applied to evaluate the significant (p-value) ratio of difference statistically. Results: In the present study, 91.1% were voluntary blood donors and rested 8.9% replacement blood, donors. Male to female ratio of blood donors were male 94% and female 6%. TTIs prevalence in the study was 1.75 % (p<0.001) while individual infections prevalence was; HbsAg 1.16, Syphilis 0.37%, HCV 0.09%, HIV 0.08%, and Malaria 0.04%. Conclusion: Low prevalence of TTIs was reported in the present study, so hereby we have concluded that a healthy transfusion service is must for the health care system of the state/country. 100% Voluntary blood donation by Regular, voluntary, non-remunerated blood donors from low-risk populations and Careful TTIs testing, preferable NAT to reduce the window period are the key factors to ensure the safe blood to the needy.