Effect of MT1M gene on the cell cycle and signaling pathway of Hep-G2 / 中华男科学杂志

<p><b>OBJECTIVE</b>To investigate the possible roles of MT1M gene on the cell cycle and signaling pathway of Hep-G2.</p><p><b>METHODS</b>Hep-G2 human hepatoma cells made by transfection with expressible MT1M gene, and the cell cycle was detected by flow cytometry, and the signaling pathway was measured by dual luciferase assay in Hep-G2 cells.</p><p><b>RESULTS</b>MT1M gene was able to induce changes of the cell cycle and the activation of NF-kappaB pathway in Hep-G2 cells.</p><p><b>CONCLUSION</b>MT1M gene may affect the cell cycle in Hep-G2 and activate the NF-kappaB-dependent transcription.</p>