ABSTRACT
Objective: To investigate the retinal nerve fiber layer (RNFL) thickness in essential tremor (ET). Methods: Twenty-seven eyes of 27 patients with essential tremor were included in this study. Twentyseven eyes of 27 healthy volunteers served as controls. All eyes were examined with spectral domain optical coherence tomography (OCT) (Retinascan Advanced RS-3000; NIDEK, Gamagori, Japan) using image filling software program (NAVIS-EX, NIDEK, Tokyo, Japan). Results: No statistically significant difference was detected between ET patients and control group for overall (RNFL) and foveal retinal thickness parameters. [RNFL thickness (Average thickness p=0.86, superior average p=0.22, inferior average p=0.24, nasal average p=0.06, temporal average p=0.88), foveal retinal thickness p=0.63] There was no relationship between OCT parameters and age, gender and duration of ET (all p>0.05). Conclusion: We did not find altered RNFL and foveal thickness values in patients with ET compared to controls. Retinal thickness changes do not seem to be a potentially useful biomarker in ET patients.
Subject(s)
Essential TremorABSTRACT
Objective: To investigate the retinal nerve fiber layer (RNFL) thickness in essential tremor (ET). Methods: Twenty-seven eyes of 27 patients with essential tremor were included in this study. Twentyseven eyes of 27 healthy volunteers served as controls. All eyes were examined with spectral domain optical coherence tomography (OCT) (Retinascan Advanced RS-3000; NIDEK, Gamagori, Japan) using image filling software program (NAVIS-EX, NIDEK, Tokyo, Japan). Results: No statistically significant difference was detected between ET patients and control group for overall (RNFL) and foveal retinal thickness parameters. [RNFL thickness (Average thickness p=0.86, superior average p=0.22, inferior average p=0.24, nasal average p=0.06, temporal average p=0.88), foveal retinal thickness p=0.63] There was no relationship between OCT parameters and age, gender and duration of ET (all p>0.05). Conclusion: We did not find altered RNFL and foveal thickness values in patients with ET compared to controls. Retinal thickness changes do not seem to be a potentially useful biomarker in ET patients.
ABSTRACT
Background & Objective:Diffusion-weighted MR imaging and apparent diffusion coefficient (ADC) values provide significant structural information about tissues in multiple sclerosis (MS).The goal of this study was to evaluate the ADC values in the hippocampus and amygdala in MS. Methods:Thirtyeightpatients with MS and 41 healthy individualswere included in the study. ADC values were measured bilaterallyfrom three different pointsin the hippocampus and amygdala in MS patients and were compared with those of the controls. An analysis of varianceposthoc test was used to analyse the differences among mean ADC values between MS and control groups.Results:The mean ADC values of both sides of thehippocampus and the left amygdala in MS patients were lower than the control group. The mean ADC values of the right amygdala in MS patients were lower than the control group, but the difference was not statistically significant. Conclusion:We observed restricted diffusion in the hippocampus and amygdala in MS patients contrary to information in the literature.