ABSTRACT
The proteasome is the main complex for specific protein degradation in eukaryotic cells, which plays a key role in protein quality control and cell homeostasis maintenance. It is found that abnormal content or function of the proteasome can lead to many human serious diseases such as cancer and neurodegenerative disorders, and several targeted drugs have been developed for the regulation of proteasome activity. Therefore, it is of great academic value and clinical significance to strengthen the research on the precise regulation mechanism of proteasome activity. The content, assembly and activity of the proteasome are regulated rigorously by multiple levels. In this paper, we summarize the composition subunits, structural features, transcriptional regulation and assembly mechanism of proteasome, and focus on the mechanistic regulation and biological significance of post-translational modifications such as phosphorylation, ubiquitination and acetylation on proteasome, which might be helpful to reveal the regulation mechanism of proteasome in the near future.
ABSTRACT
@#ObjectiveTo evaluate the clinical efficacy of intracoronary stenting for senile patients with acute myocardial infarction(AMI).Methods42 senile patients with AMI underwent intracoronary stenting were analysed. Before and after stenting, the changes of the patients' blood pressures, heart rates and cardiac functions tested by ultrasonography were observed.Results45 intracoronary stents were implanted in 42 patients, one patient falled during hospitalization. The blood pressure was increased significantly, the heart rate decreased and the candiac function improved after stenting.ConclusionIntracoronary stenting is a very effective and safe therapy for the senile patients with AMI.