Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
1.
Chinese Journal of Natural Medicines (English Ed.) ; (6): 347-354, 2017.
Article in English | WPRIM | ID: wpr-812106

ABSTRACT

The present study was designed to synthesize 2-Cyano-3, 12-dioxooleana-1, 9(11)-en-28-oate-13β, 28-olide (1), a lactone derivative of oleanolic acid (OA) and evaluate its anti-inflammatory activity. Compound 1 significantly diminished nitric oxide (NO) production and down-regulated the mRNA expression of iNOS, COX-2, IL-6, IL-1β, and TNF-α in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Further in vivo studies in murine model of LPS-induced acute lung injury (ALI) showed that 1 possessed more potent protective effects than the well-known anti-inflammatory drug dexamethasone by inhibiting myeloperoxidase (MPO) activity, reducing total cells and neutrophils, and suppressing inflammatory cytokines expression, and thus ameliorating the histopathological conditions of the injured lung tissue. In conclusion, compound 1 could be developed as a promising anti-inflammatory agent for intervention of LPS-induced ALI.


Subject(s)
Animals , Female , Humans , Male , Mice , Acute Lung Injury , Drug Therapy , Genetics , Allergy and Immunology , Anti-Inflammatory Agents , Bronchoalveolar Lavage Fluid , Allergy and Immunology , Cyclooxygenase 2 , Genetics , Allergy and Immunology , Interleukin-1beta , Genetics , Allergy and Immunology , Interleukin-6 , Genetics , Allergy and Immunology , Lipopolysaccharides , Lung , Allergy and Immunology , Macrophages , Allergy and Immunology , Mice, Inbred BALB C , Neutrophils , Allergy and Immunology , Oleanolic Acid , Peroxidase , Genetics , Allergy and Immunology , Tumor Necrosis Factor-alpha , Genetics , Allergy and Immunology
SELECTION OF CITATIONS
SEARCH DETAIL