ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation of homocysteine with diabetic microangiopathy and the change after drug intervention.</p><p><b>METHODS</b>A total of 200 patients with type 2 diabetes were selected between January and December 2013. The patients were divide into group of no microvascular disease and group of microvascular lesion according to the complications. Blood lipid, blood glucose, renal function and serum homocysteine were deteced pre-treatment and after 6 months treatment.A total of 100 cases of healthy subjects with physical examination over the same period were selected as control group according to the principle of age and gender matching.</p><p><b>RESULTS</b>SBP, DBP, TG, TC, LDL, FBG, 2 hPBG, HbA1, SUN, SCr and HCY in group of no microvascular disease and group of microvascular lesion were significantly higher than that in control group(P<0.01), while HDL were significantly lower(P<0.01); SBPDBP,SUN,SCr and HCY in group of microvascular lesion were significantly higher than that in group of no microvascular disease(P<0.01); Multi factor Logistic regression analysis showed blood pressure, urea nitrogen, serum creatinine and homocysteine levels are risk factors for microvascular complications in patients with diabetes mellitus; HCY after treatment were significantly lower than that before treatment in group of no microvascular disease and group of microvascular lesion than(P<0.01).</p><p><b>CONCLUSION</b>High homocysteine levels are risk factor of diabetic microvascular disease, and the homocysteine levels can be reduced after treatment.</p>
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the validity and reliability of the Occupational Stress Scale (OSS) for Chinese offshore oil platform workers.</p><p><b>METHODS</b>A 51-item self-administered questionnaire developed in the light of Cooper's questionnaire and company's special situation was used to investigate 561 subjects.</p><p><b>RESULTS</b>51 occupational stress items relating to offshore oil production were subjected to factor analysis, and nine latent factors were identified, which explained 62.5% of the total variance. According to the contents described by the items included in each factor, they were respectively defined as: "the interface between job and family/social life (factor 1)", "career and achievement (factor 2)", "safety (factor 3)", "management problem and relationship with others at work (factor 4)", "physical factors of workplace (factor 5)", "platform living environment (factor 6)", "role in management (factor 7)", "ergonomics (factor 8)" and "organization structure (factor 9)". Significant difference in the score of five factors was observed among 12 different job categories by analysis of variance. After adjusting for potential confounding factors (age, educational level), hierarchical multiple regression analysis indicated that the score of the OSS was significantly and positively correlated with the poor mental health of the workers (P < 0.01). The consistent test between OSS and each factor showed that Cronbach's alpha were 0.72 - 0.91.</p><p><b>CONCLUSION</b>The OSS is a valid and reliable tool for measuring occupational stress, and can be used to explore occupational stress and its influence on health and safety problems in offshore oil workers.</p>