ABSTRACT
[Objective] To explore the similarities and differences between ancient and modern physicians in treating "bone atrophy"so as to provide reference for clinical treatment of renal osteodystrophy, bone tuberculosis and osteoporosis. [Method] Summarizing the similarities and differences between ancient and modern physicians in etiology and pathogenesis and treatment of syndrome differentiation of bone atrophy by consulting the literatures. [Results] Ancient and modern physicians have connections and differences in treatment based on syndrome differentiation of bone atrophy.Ancient physicians who treated bone atrophy whose syndrome was evil invading XiGu, deficiency of spleen and kidney with coordinating meridian of Yangming, getting rid of evil obtained better effects and the syndrome of Qi deficiency and blood stasis, damage of Yin and Yang that treated with enriching Qi and activating blood, nourishing yin and tonifying yang as well. Modern physicians who treated bone atrophy whose syndrome was deficiency of spleen and kidney, dampness and blood stasis with nourishing kidney and spleen, activating blood and draining turbidity obtained certain effects and the syndrome of kidney and essence deficiency, blood and Qi stasis that treated with strengthening bones and essence, promoting flow of qi and blood as well. So as the syndrome of Yang deficiency of kidney, phlegm and blood stasis resisting meridian. [Conclusion] Ancient and modern physicians have certain effects in the treatment of bone atrophy.They both believe that Qi and blood stasis are the factors which lead to bone atrophy, therefore, activating Qi and blood as treatment of bone atrophy are both agreed.The difference is that the ancient physicians believed that the spleen and stomach deficiency was the key to the formation of bone atrophy.Coordinating Yangming meridian as treatment.Modern physicians believe that kidney deficiency and blood stasis is the key to the formation of bone atrophy.Nourishing kidney and activating blood as treatment mainly.
ABSTRACT
Objective To investigate pulmonary circulation effects of protamine different infusion ways on the acyanotic congeni -tal heart disease(CHD) patients with pulmonary arterial hypertension(PAH) after extracorporeal circulation surgery .Methods Se-lect 80 cases of the CHD patients prepared for extracorporeal circulation surgery ,according to the different routes of administration and with or without PAH ,80 patients are divided into 4 groups (n= 20) :A1(non-PAH ,aortic root administration) ,A2(non-PAH , central venous administration) ,B1(PAH ,aortic root administration ) ,B2 (PAH ,central venous administration) .pulmonary artery pressure(PAP) ,pulmonary venous pressure (PVP) ,central venous pressure (CVP) ,peak airway pressure (Ppeak) ,plateau airway pressure(Pmean ) at the time point of preoperative(T0) ,before infusion of protamine (T1) ,1 minute after infusion of protamine (T2) ,3 min (T3) ,5 min (T4) ,10 min (T5) ,15 min (T6) and 25 min (T7) were recorded .The level of venous blood thromboxane B2(TXB2) was detected .Results After infusion protamine ,the PAP ,PVP ,CVP ,Ppeak and Pmean of group A2 and group B2 are higher compared to group A1(P< 0 .05) and group B1(P< 0 .01) respectively ;Compared with preoperation (T0) ,the TXB2 in 4 groups increased obviously after infusion protamine (T2 to T7) (P< 0 .05) ;Compared with group A1 and group B1 ,the TXB2 of group A2 and group B2 increased more significantly (P< 0 .01) .Conclusion Patients with congenital heart disease after intracardi-al surgery with extracorporeal circulation use trace pump infusion protamine through the aortic root ,which have little effect on pul-monary circulation ,can significantly reduced TXB2 release compared with central vein administration ,it can avoid a high concentra-tion of protamine directly into the pulmonary circulation that can strongly stimulate the pulmonary vascular and tracheal smooth muscle .Especially in the CHD patients with PAH .