ABSTRACT
Objective To explore the relationship between the age of onset and ketosis in patients with newly diagnosed type 2 diabetes mellitus (T2DM), and to provide reference for clinical early intervention and treatment of ketosis according to the characteristics of age. Methods A single center cross-sectional study was conducted to study newly diagnosed T2DM patients who were hospitalized in the Endocrinology Department of Zhongnan Hospital of Wuhan University from January 2016 to December 2019. According to the age of onset, they were divided into young group, middle-aged group and old group. The general clinical data were analyzed and compared. Spearman correlation analysis and multivariate logistic regression were used to analyze the correlation between age and ketosis. Results The proportion of ketosis, males, overweight/obesity, MS, TyG, BMI, β-HB, and TG levels in the young group were significantly higher than those in the middle-aged and old groups, and HbA1c, HOMA-IR, MBS, and OGTT0h were significantly higher than those in the old group. HDL-C in the young group was significantly lower than that in the middle-aged group and old group, and AUGinsulin and IRT2h were significantly lower than those in the old group (P＜0.05). Spearman correlation analysis showed that age was positively correlated with HDL-C and AUGinsulin, and negatively correlated with BMI, TG, HbA1c, β-HB, HOMA-IR, and TyG (P<0.05). Multivariate logistic regression analysis showed that compared with the old group, the OR values of ketosis in the middle-aged group and the young group were 2.584 and 3.870, respectively (P<0.05). Conclusion Early onset age can increase the risk of ketosis in newly diagnosed T2DM patients, and it is necessary to strengthen early intervention and comprehensive treatment for young patients with disease onset.