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OBJECTIVE To study the influenceof clonidine on the hemadynamics and plasma catecholamine of the postoperative patients in PACU. METHODS Twenty eight patients suffered from severe OSAHS who underwent modified UPPP and monitored in the PACU after operation were divided randomly into two groups:clonidine group and control group. Both group received the same protocol of sedation and analgesia. Patients in clonidine group received clonidine 3ug/kg injected slowly when entered the PACU,and patients in control group received same volume of NS. Esmolol and Nitroglycerin were used to adjust the hemadynamics. The changing of hemadynamics was recorded,blood samples were taken before operation,2 hours after entering PACU,before discharge from PACU to determine the changing of plasma catecholamine. RESULTS The hemadynamics was more stable in clonidine group than that in control group and less vasoactive agents were needed. The plasma catecholamine was much lower in clonidine group 2 hours after entering PACU and before discharge from PACU than that in control group. CONCLUSION Clonidine could be administered to stabilize the hemadinamics,to lower the level of stress hormone and could improve the recovery of the patients.
ABSTRACT
Objective To determine the early diagnostic value of serum C -reactive protein (CRP)、 total complement( CH50 ) activity and complement 3 (C3) concentration of premature women in the subclinical infection.MethodsSolid phase enzyme linked immunosorbent assay ( ELISA method ) was used for measurements of serum CRP levels. According to modified Mayer simple tubular colorimetric method and simple agar immunodiffusion method, we determined the CH50、C3 concentration respectively.Results Premature women with subclinical chorioamnionitis showed higher serum CRP concentration than that of normal pregnancy women (P<0.01). In the subclinical chorioamnionitis, the more serious the infection, the higher the CRP concentration, while CH50 and C3 concentrations were correspondently decreased. Serum CRP concentration in premature labor was the most sensitive index that suggested subclinical chorioamnionitis. ConclusionsSerum CRP、CH50 and C3 concentrations in premature labor are simple,reliable and accurate indexes for early diagnosis of subclinical infection.