ABSTRACT
Objective To study on the of insulin secretion relations to plasma glucose and the effect of different plasma glucose levels on insulin secretion stimulated by glucose.Methods 98 patients with type 2 diabetes were undergone 75g orally glucose tolerance test(OGTT) and insulin releasing test(IRT) 48hours after stopping administration of oral hypoglycemia agent.The data of plasma levels of glucose and insulin,and the time of peak glucose and insulin and postprandial plasma gluocse and insulin ,the time of peak glucose value,the ratio of maximal glucose to base glucose on base and stimulated insulin secrtion were analyzed statistically.Results The findings demonstrated that plasma glucose of OGTT has relation to base insulin level wihle no significance ,but to stimulate insulin (I max ) of IRT and the ratio of maximal insulin to base insulin(M/B 1).I max and M/B 1 when base glucose level excess 11 1mmol/L were one third of the same index when base glucose level less than 11 1mmol/L(P
ABSTRACT
Objective To investigate the incidence of sporadic type of painless thyroiditis (SPT),to analyse its laboratory characteristics, and explore the influence of different treatments on prognosis. Methods 43 patients with SPT, who differentiated from 276 patients with typical thyrotoxicosis, were randomly divided into treatment group (n=22) and control group(n=21).Results the incidence of SPT was 15 58%,the laboratory examinations in SPT differed from those of Graves disease, Plummer's disease and Hoshimotos disease. In treatment group the thyrotoxicosis continued(37 23?4 28) days, the euthyroidism continued(16.43?3.42) days and hypothyroxinemia continued(18.65?6.31)days,only one patients(4.54%) showed that repeated episode and had not left lifelong hypothyroidism; In control group the thyrotoxicosis continued(68 35?8 32) days, the euthyroxinemia continued(31 45?7 23) days and the hypothyroxinemia continued(102 42?21 34) days, 3 patients(14 28%)showed that repeated episodes and two patients(9 52%) left lifelong hypothyroidism in following 1 5 years;Conclusions SPT has less incidence than Grave's disease and more incidence than plummer's disease or Hoshimoto's disease in thyrotoxicosis. The laboratory examination could differentiate each other .The therapy of SPT could control thyrotoxicosis quickly,reduce recurrence rate and lifelong hypothyroidism.
ABSTRACT
Objective To investigate the cause, the clinical manifestation, the diagnosis and the treatment of subacute thyroiditis. Methods The medical history, clinical characteristics, laboratory data, nuclear medicine tests and treatment of 76 cases of subactue thyroiditis were analyzed. Results Subacute thyroiditis was more common in women than men, and 76 3% cases with subacute thyroiditis occurred during 30～49 years old. Almost all cases were characterized by enlargement of the thyroid with pain and tenderness, 49 cases of which showed that radioiodine uptake was low with increased serum thyroid hormone levels. 25 cases were treated with prednisone, 23 cases were treated with intrathyroid injection of dexamethasone, 23 cases were treated with intrathyroid injection of dexamethasone and triamcinolone, all recovered well, and 5 cases underwent operation incorrectly. Conclusions Confirmation of subacute thyroiditis should put emphasis on a complete medical history, physical examination and necessary tests. Nuclear medicine tests play an important role in diagnosis of subacute thyroiditis, and the diagnostic drug treatment or fine needle aspiration biopsy may be performed in suspected cases. Glucocorticoid is the best medicine for treating this kind of disease. There is no need for operation therapy of subacute thyroiditis.