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1.
Chinese Journal of Oncology ; (12): 511-514, 2010.
Article in Chinese | WPRIM | ID: wpr-260364

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the prognostic significance of Her-2 expression in node-positive and node-negative breast cancer in Chinese women.</p><p><b>METHODS</b>The Her-2 expression in breast cancers from 981 patients was detected by immunohistochemistry with anti-Her-2 (CB11) monoclonal antibody. The survival curves were analyzed by Kaplan-Meier method, and Cox regression model was applied to determine whether this factor is an independent predictor of survival in multivariate analysis.</p><p><b>RESULTS</b>Nineteen point seven percent of the patients showed positive Her-2 expression in their tumors. Patients with Her-2-positive tumors tended to be younger. The high level Her-2 expression was significantly associated with negative estrogen receptor and progesterone receptor status in their tumors (P < 0.05). Among 387 patients with node-positive disease, the 5-year disease-free survival (DFS) rate and 5-year overall survival (OS) rate were significantly lower in patients with Her-2-positive tumors than in patients with Her-2-negative tumors (DFS: 48.8% vs. 66.9%, P = 0.009; OS: 55.2% vs. 76.4%, P = 0.001), and Her-2 expression was an independent unfavorable prognostic factor for OS, but not for DFS in patients with node-positive disease. Among 591 patients with node-negative disease, Her-2 expression was not significantly associated with DFS and OS (P > 0.05).</p><p><b>CONCLUSION</b>Her-2 expression is an important prognostic factor in patients with node-positive disease, but not for patients with node-negative disease in Chinese women.</p>


Subject(s)
Adult , Aged , Aged, 80 and over , Female , Humans , Middle Aged , Age Factors , Breast Neoplasms , Metabolism , Pathology , Disease-Free Survival , Follow-Up Studies , Gene Expression Regulation, Neoplastic , Lymph Nodes , Pathology , Lymphatic Metastasis , Neoplasm Staging , Proportional Hazards Models , Receptor, ErbB-2 , Metabolism , Receptors, Progesterone , Metabolism , Survival Rate
2.
Chinese Journal of Surgery ; (12): 282-284, 2004.
Article in Chinese | WPRIM | ID: wpr-311129

ABSTRACT

<p><b>OBJECTIVE</b>To discuss the effects of breast-conserving therapy in Chinese women with early primary breast carcinoma.</p><p><b>METHODS</b>Ninety-five patients with stage I to II primary breast cancer were operated with wide local excision and axillary lymph node dissection. After operation, the radiation therapy was done on the whole breast.</p><p><b>RESULTS</b>Breast conservation surgery was taken successfully in ninety-five patients. Six months after operation, the approval rate for their breast was 100% by themselves. Ninety-two per cent of them were very satisfactory. After a median follow-up of 17 months (range 2 - 51 months), only one patient suffered from ipsilateral breast tumor relapse. The two years local relapse rate was 1.4%. There were no cases of distant relapse and death.</p><p><b>CONCLUSIONS</b>The early results of breast-conserving therapy are satisfactory for stage I to II primary breast cancer. The long-term follow-up is needed for the final outcome.</p>


Subject(s)
Adult , Aged , Female , Humans , Middle Aged , Adenocarcinoma , Radiotherapy , General Surgery , Breast , Pathology , Radiation Effects , General Surgery , Breast Neoplasms , Radiotherapy , General Surgery , Combined Modality Therapy , Follow-Up Studies , Recurrence , Surgical Procedures, Operative , Methods , Treatment Outcome
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