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Objective To evaluate the related factors in 3.0T MR imaging features for predicting triple negative breast cancer (TNBC).Methods Totally 191 patients with breast cancer confirmed by histopathology were enrolled,among them 25 were TNBC (TNBC group),while the other 166 were non-TNBC (non-TNBC group).All patients underwent 3.0T MR examination.Patient age,tumor size,shape,margin,enhancement pattern,signal intensity on T2WI,time-intensity curve (TIC),ADC value,and peritumoral vessel between the two groups were compared.Univariate and multivariate Logistic regression analyses were used to predict the related factors.Results Compared with non-TNBC group,smooth margin (P=0.023),round mass (P=0.001),rim enhancement (P＜0.001),high signal intensity on T2WI (P=0.003),higher ADC value (P=0.022) and increased peritumoral vessel (P=0.046) were significantly associated with TNBC.Further multivariate Logistic regression analysis identified four independent risk factors of TNBC (all P＜0.05),including enhancement pattern,signal intensity on T2WI,ADC value and increased peritumoral vessel.The area under ROC curve of combination of the 4 factors was 0.840.Conclusion Rim enhancement of mass,high signal intensity on T2WI,higher ADC value,and increased peritumoral vessels are independent risk factors in predicting TNBC.
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Objective:To explore the lactate metabolism in brain tissue of the mice with early acute hypoxia-ischemia injury,and to provide data support for 9.4T 1 H-NMR spectroscopy in detecting the lactate level clinically.Methods:Eighty Kunming mice were randomly divided into sixteen groups (0 s,20 s,40 s,60 s,2 min,4 min, 6 min,8 min, 10 min, 12 min, 14 min, 16 min, 18 min,and 20 min)according to the duration of hypoxia-ischemia (n=5).The changes of lactate levels were detected by 9.4T 1 H-NMR spectroscopy. Results:After the initiation of hypoxia-ischemia injury,the lactate level began to increase rapidly to the highest value of (6.89 ± 0.34)μmol·g-1 at 20 s,then started to decline quickly from 40 s to 2 min,and eventually decreased to a stable level of (4.85±0.36)μmol·g-1 until 6 min.Compared with control group,the levels of lactate in brain tissue of the mice in hypoxic-ischemic groups were increased (P <0.01).Conclusion:40 s of acute hypoxia-ischemia may be the lactate cerebral neuron threshold during the anaerobic glycolysis. 9.4T1 H-MRS can provide the exact time window for detecting the lactate metabolism.
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Objective To investigate the relationship between CT characteristics and histological differentiation of soft tissue sar-comas.Methods Forty-two cases with pathologically proved soft tissue sarcomas were collected.The tumor size,morphology,den-sity and relationship of the tumor to the adjacent structures on CT were analyzed retrospectively.The value of the CT signs in evalu-ating the histological differentiation of the tumor was explored.Results The maximal diameter of the tumor was over 5 cm in 36 ca-ses.Oval shape was seen in 29 cases and irregular shape was seen in 13 cases.Heterogeneous density was seen in 32 cases including intratumoral calcification in 3 cases and intratumoral necrosis in 22 cases.Adjacent structures were infiltrated in 25 cases.Compared to the pathological results,intratumoral necrosis and invasion of adjacent structures were related to the degree of histological differ-entiation (P <0.05),and the relation coefficients were 0.64 and 0.57,respectively (P <0.01).Conclusion Intratumoral necrosis and invasion of adjacent structures are correlated with the histological differentiation of the soft tissue sarcomas.They may reflect the biological behavior of low-differentiated or undifferentiated soft tissue sarcomas to some extent.
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Among the different x-ray features of breast carcinoma, mass and calcification are the most significant reference parameters in the screening and diagnosis of early carcinoma. Mammographic follow-up after conservation therapy is the other important value of mammography for breast carcinoma. Calcification is the most important sign to show residue or recurrence of conservation therapy.