ABSTRACT
Objective To develop an identification model of raceanisodamine tablets by diffuse reflection near -infrared spec-troscopy and pattern recognition .Methods The diffuse reflectance spectra in the 12 000-4 000 cm-1 spectral coverage range of racean-isodamine tablets from eight different pharmaceutical factories were collected to establish the identification model .A mono-component near infrared model was established for raceanisodamine tablets .Results The parameters of the identification model for the raceaniso-damine tablets was as follows:spectral range was 5 400-7 000 cm-1 ,the pretreatment method was first derivative and normalization;the threshold was 0.603.And the model was validated , which met the requirements of application .Conclusion The results showed that identification model for the raceanisodamine tablets by near infrared spectroscopy was feasible , which provided a reference method for the model updating .
ABSTRACT
Objective:To establish an HPLC method for the determination of thymol in thymol alcoholic solutions. Methods: An Agilent Eclipse XDB-C18(250 mm ×4.6 mm,5μm) column was used with the mobile phase of methanol-water (65∶35), the flow rate was 1. 0 ml·min-1 . the detection wavelength was 275nm, the injection volume was 10μl, and the column tenperature was 25℃. Re-sults:A good linear correlation of thymol was observed within the range of 60-160 μg·ml-1(r=0. 999 5). The average recovery was 101. 59% with RSD of 1. 39%(n=9). Conclusion:The method is quick, simple and accurate, which can be used in the determina-tion of thymol alcoholic solutions with good selectivity and sensitivity.
ABSTRACT
Powder X-ray diffraction (PXRD) technology combined with cluster analysis method was used to classify 75 batches of crystalline ceftriaxone sodium into subtypes, the crystalline characteristics of each subtype were measured with scanning electron microscope (SEM). By comparing some parameters of these subtypes correlated to crystallization process of ceftriaxone sodium, such as salification rate, water content in different subtypes, as well as by studying different lattice stabilities, different compatibilities with rubber closures during accelerated stability tests, the key point to improve the quality of domestic ceftriaxone sodium was disclosed. The results of this paper indicated that the fine structure of the products could be controlled well by improving the salification and crystallization process. As a result, the subtype II of ceftriaxone sodium with high stability can be produced.